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EC number: 209-667-4 | CAS number: 589-98-0
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradation rate constant of test chemical 3-Octanol was determined to be 905 per hrs by using activated sludge as inoculums and test material analysis by GC as parameter. On the basis of this rate constant value it can be concluded that test chemical is biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2018) prediction model was run to predict the half-life in water and sediment for the test compound 3 -octanol (CAS No.589 -98 -0). If released in to the environment, 32.3 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 8.66 days (208 hrs). The half-life (8.66 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical 3-octanol in sediment is estimated to be 77.91 days (1870 hrs). This half life value indicates that test chemical 3 octanol is not persistent in sediment.
Biodegradation in soil:
The half-life period of test chemical 3-Octanol (CAS No.589 -98 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2018). If released into the environment, 65 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 3-Octanol in soil is estimated to be 17.33 days (416 hrs). Based on this half-life value of test chemical 3-Octanol, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .
Additional information
Biodegradation in water:
Experimental data and Predicted data studies for the target compound3-octanol (CAS no. 589-98-0)and experimental studies for its structurally similar read across substance were reviewed for the biodegradation end point and their results are summarized as below.
First study was an experimental study reviewed from chemosphere journal (1979) in this study biodegradation experiment was conducted to determine biodegradation rate constant of test chemical 3-octanol (CAS no. 589-98-0) in this experiment activated sludge was obtained at the end of an aeration period from the semi-continuous culture maintained with peptone-glucose synthetic waste in the laboratory. After washing with a M/50 phosphate buffer (pH 7) it was used in the experiments. Following medium was used 81.5 mg of KH2P04, 196 mg of Na2HPO4, 10 mg of MgSO47H20 , 1.0 mg of FeSO47H20 , 10 mg of urea, 2.0 m% of ethanol, and water in 200 mL Erlenmeyer flask concentration of test chemical used was 0.05 ml/L. Then test material was anlyzed by gas chromatography. Biodegradation rate constant of test chemical 3-Octanol was determined to be 905 per hrs by using activated sludge as inoculums and test material analysis by GC as parameter. On the basis of this rate constant value it can be concluded that test chemical is biodegradable.
Next study was predicted data study done by using Estimation Programs Interface Suite (EPI suite, 2018) to estimate the biodegradation potential of the test compound 3-Octanol (CAS no. 598 -89 -0) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 3-Octanol is expected to be readily biodegradable.
In another predicted data study biodegradability of test chemical 3-Octanol (CAS no. 589-98-0) was estimated by using OECD QSAR tool box v3.3 by considering seven closest read across chemical with molecular weight as primary descriptor. Percent biodegradation of the test chemical 3-Octanol was estimated to be 83.07 % by considering BOD as parameter and Microorganism as inoculum in 28 days. On the basis of percent degradability value it can be concluded that test chemical 3-Octanol is readily biodegradable.
Next study was experimental study done from authoritative database (J check, 2018) in this study the Biodegradation experiment was carried out of structurally similar read across chemical 2-Octanol (CAS no. 123-96-6) by taking activated sludge as inoculums at 30 mg/L concentration for 14 days. Biodegradation was analyzed by using three parameters that are BOD, TOC removal and test material analysis by GC. The initial concentration of read across chemical was 100 mg/L. After 2 weeks of incubation percent biodegradation of read across chemical 2-Octanol was observed to be 76 % by O2 consumption (BOD) parameter 96 % by TOC removal parameter and 100% degradation by test material analysis by GC parameter in 14 days. Therefore it is concluded that read across chemical 2-Octanol is readily biodegradable.
Last study was also experimental study done from authoritative database (J check, 2018) in this study the Biodegradation experiment was carried out of read across chemical 2-Ethylhexyl alcohol (CAS no. 104-76-7) by taking activated sludge as inoculums at 30 mg/L concentration for 14 days. Biodegradation was analyzed by using three parameters that are BOD, TOC removal and test material analysis by GC. The initial concentration of read across chemical was 100 mg/L. After 2 weeks of incubation percent biodegradation of read across chemical 2-Ethylhexyl alcohol was observed to be 89.5 % by O2 consumption (BOD) parameter and 100 % by both TOC removal parameter and test material analysis by GC parameter in 14 days. Therefore it is concluded that chemical 2-Ethylhexyl alcohol is readily biodegradable.
On the basis of results of above mentioned studies for target chemical 3-octanol (CAS no. 589-98-0)(from Chemosphere journal, OECD QSAR tool boxv3.3 and EPI suite) and supporting weight of evidence study (from J Check, 2018). It is concluded that the test chemical 3-octanol (CAS no. 589-98-0)can be expected to be readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2018) prediction model was run to predict the half-life in water and sediment for the test compound 3 -octanol (CAS No.589 -98 -0). If released in to the environment, 32.3 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 8.66 days (208 hrs). The half-life (8.66 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical 3-octanol in sediment is estimated to be 77.91 days (1870 hrs). This half life value indicates that test chemical 3 octanol is not persistent in sediment.
Biodegradation in soil:
The half-life period of test chemical 3-Octanol (CAS No.589 -98 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2018). If released into the environment, 65 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 3-Octanol in soil is estimated to be 17.33 days (416 hrs). Based on this half-life value of test chemical 3-Octanol, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .
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