Registration Dossier
Registration Dossier
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EC number: 275-912-7 | CAS number: 71720-84-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April from 06 to 30, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Reason / purpose for cross-reference:
- reference to other study
- Remarks:
- validation of analytical method
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- adopted on 27 July 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 16.33 g/L
- Temp.:
- 20 °C
- pH:
- 8
- Details on results:
- The solubility of test item in milli-Q water was determined to be 16.28 g/l, 16.36 g/l and 16.36 g/l for the three replicates 24, 48 and 72 hours respectively. The mean water solubility was 16.33 g/l at pH 8.0, with 0.28 % RSD at 20 °C by Shake flask method within the limit of 15 % for three time points.
- Conclusions:
- 16.33 g/l at 20 °C and pH 8
- Executive summary:
The water solubility of the test item was determined in accordante with the method and procedures outlined into the OECD guideline 105.
A preliminary test for solubilitywas carried out for the decision whether the column elution method or the flask method has to be used for the performance of the main test. The solubility of the test item resulted to be more than 10-2 g/l. Therefore, the flask method was used for the main test.
The concentration in the clear aqueous phase was determined by HPLC-UV validated method. The pH of each sample was recorded.
The definitive test was performed in milli-Q water under laboratory condition at 20 °C and by Shake Flask Method. The samples were analyzed for test item concentration by high performance liquid chromatography. The solubility of test item in milli-Q water was determined to be 16.33 g/l at 20 °C and pH 8.0, with 0.028 % of RSD.
Conclusion
16.33 g/l at 20 °C and pH 8
Reference
| Hours | Test item content (g/l) |
| 24 hours | 16.28 |
| 48 hours | 16.36 |
| 72 hours | 16.36 |
Average |
16.33 |
SD |
0.046 |
% RSD |
0.28 |
Description of key information
16.33 g/l at 20 °C and pH 8
Key value for chemical safety assessment
- Water solubility:
- 16.33 g/L
- at the temperature of:
- 20 °C
Additional information
OECD 105 - Flask Method
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