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EC number: 821-762-8 | CAS number: 4563-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Structural similarities are observed between target substance Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts (CAS 4563-56-8) and source substance Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (CAS 4259-15-8) substance. They contain the same functional groups with difference in alkyl ester chain, where the target is composed of linear dodecyl chains and source of branched ethylhexyl chains. Comparing the fatty alcohols of the raw substances involved in the reaction, 2-ethylhexanol is much more soluble in water than dodecanol, correspondingly the Pow values of 2-ethylhexanol is lower the that of dodecanol. However, target and source substances reveals the different patterns of physicochemical parameters as set out in the Table below, implying that properties of the target and source substances are dominantly determined by the chelated molecular structure of dialkyldithiophosphoric acid and Zn than the form and length of alkyl chains. Therefore the target and source substances may have the similar behaviour in the toxicological aspects.
Due to complex molecular structures and conversable forms in the aqueous solution, determination of a pH-dependent hydrolysis is technically difficult and unreliable.
The source substance is not readily biodegradable. Less than 5% biodegradation was observed for the source substances in screening tests for ready biodegradation. Hence the substance can be considered as not biodegradable in water. Based on these results the conclusion might be drawn that both substances are poorly biodegradable. Both substances belong to the group of zinc dialkyldithiophosphates, which consist of a phosphorodithioic acid structure with alkyl or alkaryl ester substituent groups. Thus, target and source substance contain the same functional groups and only have difference on alkyl chain length (C12 in target substance and C8 in source substance). These structural similarities suggest the similar bioavailability. Therefore, poor biodegradability should apply also to the target substance.
Furthermore, the target and source substances have a moderate water solubility (150 mg/L and 9.1 mg/L respectively) and a low vapour pressure (<4.0 x 10-2 Pa at 20 °C) and therefore are non-volatile. The water solubility of 150 mg/L was the mean value of 0.16 g/L at 23 °C and pH 5.75, based on phosphorus and 0.14 g/L at 23 °C and pH 5.75, based on sulphur).
The partition coefficient of target substances was determined obtained to be between 3.4 and 5.6 at 20 °C, in two by means of HPLC determinations. In the study of determination of partition coefficient, two peaks show in the HPLC chromatogram during the measurement of logPow, which implies the complex structures of ZDDP: The monomeric or dimeric neutral forms together with basic form are present in the substance. The basic form might less water soluble than the neutral forms, therefore might have a higher logPow than the neutral forms. Based on this assumption it can be concluded that the logPow value of 5.6 determined by HPLC belongs to the basic form of ZDDP, whereas the logPow value of 3.4 is obtained because of neutral forms.
The log Pow values of target and source substance are considered to be comparable at the same level and deviations reflect the method variance. The neutral forms and basic form of the molecule could be probably not distinguished by GC-MS, whereas can be separated by HPLC. Due to this reason, it is expected that if the log Pow of target substance measured by means of derivatisation followed by GC-MS, only the value of 3.4 will be obtained.
Endpoint |
Target: CAS 4563-56-8 |
Source: CAS 4259-15-8 |
Biodegradability |
RA CAS 4259-15-8 |
Experimental result: not readily biodegradable |
Bioaccumulation |
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Adsorption/desorption |
Waiver |
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