Registration Dossier
Registration Dossier
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EC number: 202-800-7 | CAS number: 99-91-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data from collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Zur Pharmakologie einiger 1,3-Dioxolane, 1,3-Oxathiolane und 1,3-Dithiolane
- Author:
- Bekemeier H., Köster D.
- Year:
- 1 976
- Bibliographic source:
- Pharmazie 31, H. 5 (1976)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: LD 50 determined in acute toxicity study using 36 mice with an observation time of 24 h.
- Short description of test conditions: not specified
- Parameters analysed / observed: LD50 - GLP compliance:
- not specified
Test material
- Reference substance name:
- 4'-chloroacetophenone
- EC Number:
- 202-800-7
- EC Name:
- 4'-chloroacetophenone
- Cas Number:
- 99-91-2
- Molecular formula:
- C8H7ClO
- IUPAC Name:
- 1-(4-chlorophenyl)ethan-1-one
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Agnes-Bluhm
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- body weight 18-22 g
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: water suspension and Tween 80
- Details on oral exposure:
- not documented
- Doses:
- not documented
- No. of animals per sex per dose:
- 36 mice in total, no further information given
- Details on study design:
- Observation: 24 h post exposure
- Statistics:
- according to Litchfield J. T. jr. and Wilcoxon F., J. Pharmacol. exp. Therapeut, 96, 97 (1949)
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 207 mg/kg bw
- 95% CL:
- >= 1 150 - <= 1 267
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
Mouse LD50 oral 1207 mg/kg was documented in the study of Bekemeier and Köster 1976. Based on this result 4 -chloroacetophenone needs to be classified in category 4 based on GHS criteria, acute tox. 4, H 302.
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