Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute dermal toxicity study in Rabbit for CAS no: 4394-85-8
Author:
GESTIS SUBSTANCE DATABASE
Year:
2017
Bibliographic source:
Institute for occupational safety and health of the German social accident insurance.2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of morpholine-4-carbaldehyde was performed in Rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Constituent 1
Reference substance name:
morpholine-4-carbaldehyde
Cas Number:
4394-85-8
Molecular formula:
C5H9NO2
IUPAC Name:
morpholine-4-carbaldehyde
Details on test material:
- Name of test material (as cited in study report):morpholine-4-carbaldehyde
- Molecular formula :C5H9NO2
- Molecular weight :115.131g/mole
- Substance type:organic
- Physical state:solid
- Purity:No data available
- Impurities (identity and concentrations):No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report):morpholine-4-carbaldehyde
- Molecular formula :C5H9NO2
- Molecular weight :115.131g/mole
- Substance type:organic
- Physical state:solid
- Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
18300mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 18 300 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No Mortality was observed
Mortality:
No mortality was observed
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be >18300mg/kg body weight. When rabbits were treated with morpholine-4-carbaldehyde (4394-85-4) by dermal application.
Executive summary:

Acute dermal toxicity study was done in rabbit using morpholine-4-carbaldehyde (4394-85-4).No mortality was observed at dose 18300mg/kg bw .Hence LD50 was considered to be >18300mg/kg body weight on dermal application