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EC number: 215-523-1 | CAS number: 1328-51-4 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 74180.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Disulfo copper phthalocyanine amine salt (CAS no 1328-51-4) ) and it’s structurally similar read across Phthalocyanine, metal free is likely to be non hazardous by oral route of exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Acute oral toxicity study of Direct Blue 86 in rats
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Direct Blue 86 (Disulfo copper phthalocyanine amine salt)
- Molecular formula (if other than submission substance): C32H14CuN8O6S2.2Na
- Molecular weight (if other than submission substance): 780.1706 g/mole
- Substance type: Organic - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- - Other examinations performed: clinical signs were observed
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No effect on survival and clinical sign
- Mortality:
- No mortality was observed in treated rats at 5000 mg/kg bw
- Clinical signs:
- other: No signs of toxicity were observed in treated rats at 5000 mg/kg bw
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be > 5000 mg/kg bw when rat were treated with Direct Blue 86 (Disulfo copper phthalocyanine amine salt) orally.
- Executive summary:
In a acute oral toxicity study,rats were treated with Direct Blue 86 (Disulfo copper phthalocyanine amine salt) in the concentration of 5000 mg/kg bw. No effect on survival and clinical signs of toxicity were observed in treated rats at 5000 mg/kg bw. Therefore, LD50 was considered to be > 5000 mg/kg bw whenrat were treated with Direct Blue 86 (Disulfo copper phthalocyanine amine salt) orally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from peer-reviewed journal
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
In different studies, Disulfo copper phthalocyanine amine salt has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for Disulfo copper phthalocyanine amine salt along with the study available on structurally similar read across substance Phthalocyanine, metal free (CAS no 574-93-6) and pigment blue 15 (CAS no 147-14-8).
In a acute oral toxicity study by Leistet al(Ecotoxicology and Environmental Safety (1982), 6(5), 457-63), rats were treated with Disulfo copper phthalocyanine amine salt in the concentration of 5000 mg/kg bw. No effect on survival and clinical signs of toxicity were observed in treated rats at 5000 mg/kg bw. Therefore, LD50 was considered to be > 5000 mg/kg bw whenrat were treated with Disulfo copper phthalocyanine amine salt orally.
In another study by ChemIDplus Toxnet Database (2017), rats were treated with Disulfo copper phthalocyanine amine salt in the concentration of 5000 mg/kg bw. No effect on survival of treated rats were observed at 5000 mg/kg bw. Therefore, LD50 was considered to be > 5000 mg/kg bw when rat were treated with Disulfo copper phthalocyanine amine salt orally.
Also it is further supported experimental data conducted given by Commission of the European Communities (1988) on structurally similar the read across substance Phthalocyanine, metal free (CAS no 574-93-6), rats were treated with Phthalocyanine, metal free in the concentration of 6000 mg/kg bw. No effect on survival were observed in treated rats at 6000 mg/kg bw. Therefore, LD50 was considered to be > 6000 mg/kg bw when rat were treated with Phthalocyanine, metal free orally.
In supporting above similar source for anther structurally similar read across substance pigment blue 15 (CAS no 147-14-8),rats were treated with pigment blue 15 in the concentration of 4600 mg/kg bw. No effect on survival were observed in treated rats at 4600 mg/kg bw. Therefore, LD50 was considered to be > 4600 mg/kg bw when rat were treated with pigment blue 15 orally.
Thus, based on the above studies on Disulfo copper phthalocyanine amine salt (CAS no 1328-51-4) and its structurally similar read across Phthalocyanine, metal free (CAS no 574-93-6) and pigment blue 15 (CAS no 147-14-8), it can be concluded that LD50 value is less than 2000 mg/kg bw. Thus comparing this value with the criteria of CLP regulation, Disulfo copper phthalocyanine amine salt can be “Not classified” for acute oral toxicity.
Justification for classification or non-classification
Based on the above available data for target Disulfo copper phthalocyanine amine salt (CAS no 1328-51-4) and its structurally similar read across Phthalocyanine, metal free (CAS no 574-93-6) and pigment blue 15 (CAS no 147-14-8) is likely to be non hazardous by oral route of exposure.
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