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EC number: 700-490-2 | CAS number: 36635-56-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- yes
- Remarks:
- Since concentrations were below the detection limit at the end of exposure, values based upon initial concentration. Validity criterion for maintaining the conc over the test period is not fulfilled.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-[[(4-methylphenyl)sulfonyl]methyl]formamide
- EC Number:
- 700-490-2
- Cas Number:
- 36635-56-0
- Molecular formula:
- C9H11NO3S
- IUPAC Name:
- N-[[(4-methylphenyl)sulfonyl]methyl]formamide
- Details on test material:
- - Name of test material (as cited in study report): CGA 224433
- Physical state: white solid
- Analytical purity: 100%
- Lot/batch No.: P.709027
Constituent 1
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Common name: Scenedesmus subspicatus
- Strain: Cambridge 276/20
- Initial cell density: 1.27*1E4 cells/ml
- Preculture: 3 days under test conditions
Study design
- Test type:
- static
- Water media type:
- not specified
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 24 ± 2°C
- Nominal and measured concentrations:
- Actual concentration: 3.0, 8.8, 29, 55, 130, 240mg/ml
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100ml Erlenmeyer flasks stoppered with aluminium caps
- Type: closed
- Material, size, headspace, fill volume: 50ml test solution
- Aeration: none
- Initial cells density: 1.27*1E4 cells/ml
- No. of vessels per concentration (replicates): 3 replicates per test concentration
- No. of vessels per control (replicates): 6 replicates for blank
OTHER TEST CONDITIONS
- Photoperiod: continuous illumination
- Light intensity and quality: approx 8000 lux (120µE/m2sec)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: [counting chamber; electronic particle counter; fluorimeter; spectrophotometer; colorimeter] TOA cell counter
- pH: at start and end of exposure
TEST CONCENTRATIONS
- Test concentrations: 18, 32, 58, 100, 180 and 320mg/ml
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 38 mg/L
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- growth rate
- Remarks on result:
- other: none
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 3 mg/L
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- growth rate
- Remarks on result:
- other: none
- Duration:
- 72 h
- Dose descriptor:
- EC0
- Effect conc.:
- ca. 3 mg/L
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC100
- Effect conc.:
- >= 240 mg/L
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- growth rate
- Details on results:
- Calculations:
EC50 results were calculated according to BERKSON, JASA 48 (1953), 569-599
EC values graphically determined on gausso-logarithmic probability paper.
NOEC was calculated according to DUNNETT, C.W., JASA 50 (1955), 1096-1121, Biometrics 20 (1964), 482-491, and modified by MARCUS et al., Biometrika 63 (1976), 655-660.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Remarks:
- Since concentrations were below the detection limit at the end of exposure, values based upon initial concentration. Validity criterion for maintaining the conc over the test period is not fulfilled.
- Conclusions:
- Testing for acute toxicity of CGA 224433 to Green Algae showed evidence of reduction in growth and thus deemed harmful to green algae.
- Executive summary:
Testing was carried out to determine the effects (if any) of CGA 224433 upon Green Algae.
It was evident from the testing that reduced growth did occur and that a classification of effects to the environment is required.
An EbC50 72 hr value was be calculated at 38 mg/ml and NOEbC 72 hr value of 3.0 mg/ml
This substance should therefore be classified as R52 harmful to the environment and R53 may cause long-term adverse effects in the aquatic environment according to EU criteria (DSD) and Acute Hazards Category: Chronic III according to GHS.
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