Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 270-109-8 | CAS number: 68411-20-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- Two male and 2 one female rabbit were applied the undiluted test substance for 24 hours. The animals were examined for mortality, clinical signs and a gross pathology was performed on survivors on day 14.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Butanal, reaction products with aniline
- EC Number:
- 270-109-8
- EC Name:
- Butanal, reaction products with aniline
- Cas Number:
- 68411-20-1
- IUPAC Name:
- aniline; butanal
- Details on test material:
- CP 6096 = butanal, reaction products with aniline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 5010 or 7940 mg/kg bw.
- No. of animals per sex per dose:
- 5010 mg/kg bw: 1 animal (male)
7940 mg/kg bw: 2 animals (male and female) - Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 7 940 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died.
Any other information on results incl. tables
Signs of intoxication: reduced appetite and activity four to seven days. The survivors showed areas of slight liver dicoloration.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
Two male and 2 one female rabbit were applied the undiluted test substance in doses of 5010 or 7940 mg/kg bw for 24 hours. The animals were exmained for mortality, clinical signs and a gross pathology was performed on surviviers on day 14. None of the animals died.
Therefore the LD50 is > 7940 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
