Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-877-1 | CAS number: 75-54-7
Endpoint summary
Administrative data
Description of key information
The are no data regarding the repeated dose toxicity of dichloro(methyl)silane, therefore data from a substance structurally-related to the hydrolysis product (dimethylsilanediol, DMSD, CAS 1066-42-8) have been used to read-across. In this OECD 422 study (Dow Corning Corporation, 2009), Sprague-Dawley rats in the toxicity phase of the study were dosed for 28/29 days. The NOAEL was based on hepatic protoporphyrinosis in males at the higher dose of 500 mg/kg bw/day. As has been demonstrated by the acute toxicity and irritation/corrosion data, there would also be corrosive local effects from HCl if dichloro(methyl)silane were to be administered. There are no reliable repeated dose toxicity data for the dermal and inhalation routes.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 250 mg/kg bw/day
Additional information
There are no reliable repeated dose toxicity data on the test substance, so good quality data from DMSD have been used to fill the data gap. This substance is a close structural analogue of the hydrolysis product of dichloromethylsilane, methylsilanediol.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver
Justification for classification or non-classification
The available read-across data on DMSD suggest that the key systemic effect (hepatic protoporphyrinosis) was only observed at a dose greater than 250 mg/kg bw/day. Therefore there is no justification to classify for repeated dose systemic toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
