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EC number: 212-485-8 | CAS number: 822-06-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 746 mg/kg bw
- Quality of whole database:
- The studies are of sufficient quality (Klimisch score=2)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 124 mg/m³ air
- Quality of whole database:
- The study is GLP compliant and is of high quality (Klimisch score=1)
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 7 000 mg/kg bw
- Quality of whole database:
- The study is of sufficient quality (Klimisch score=2)
Additional information
Acute toxicity: oral
The LD50 resulting from a single oral (gavage) administration ranged from 746 to approximately 959 mg/kg bw for the male rat (Smyth et al., 1969; Union Carbide Corp., 1964; Kimmerle et al., 1970). Soon after dosing the animals appeared to be extremely sluggish. All deaths occurred within the first day.
Acute toxicity: dermal
The acute dermal toxicity of HDI was low with an LD50 value > 7000 mg/kg bw for male and female rats according to OECD TG 402 (Mürmann, 1985). Single occlusive administration of 7000 mg/kg bw for 24 hours was tolerated without mortalities. The animals showed clinical signs (rough hair, crusts and scars in application area) up to the end of the 14-day observation period. Body weight gain was transiently inhibited. Gross necropsy revealed hyperemia and swelling of the gastric mucosa as well as distinct hyperemia of the small intestine mucosa, peritoneum, pleura, diaphragm and pancreas in all animals.
Acute toxicity: inhalation
The inhalation LC50 in rats of both sexes was determined to be 124 mg/m3 for 4 hours of exposure to HDI vapour according to OECD TG 403 (Pauluhn, 1997). Exposures to concentrations of 55 mg/m3 and above were followed by concentration-dependent signs indicative of respiratory tract irritation, such as bradypnea, dyspnea, laboured breathing pattern, rales, nostrils/muzzle with red encrustations, cyanosis, prostration (lying on belly), reduced motility, ungroomed haircoat, hypothermia, decreased body weights, and piloerection. Gross necropsy revealed less collapsed, discolorated (dark-red) lungs with serous mucus in trachea. The lung associated lymph nodes were enlarged. Clinical observations and necropsy findings support the conclusion that a causal relationship between lethality and lung damage existed.
Two sensory irritation studies with HDI vapour revealed 30-minute RD50 values (50 % inhibition of respiration) of 9.93 mg/m3 in male rats (Sangha, 1982) and of 2.45 mg/m3 in male mice (Sangha et al., 1981). In rats, time-response relationships showed a fast onset of the response and development of tolerance after five minutes of exposure. However, fast recovery after short exposure and slow recovery after longer exposure were observed in mice.
Justification for classification or non-classification
Acute toxicity: oral
Not classified under Annex I of Directive 67/548/EEC or Annex VI-1 of Regulation (EC) No 1272/2008. Differing from this oral LD50 values of 746-959 mg/kg bw for the male rat lead to the following classification according to Annex I of Regulation (EC) No 1272/2008: Category 4 (H302: Harmful if swallowed).
Acute toxicity: dermal
Not classified under Annex I of Directive 67/548/EEC. According to Annex I of Regulation (EC) No 1272/2008 no classification is required for acute dermal toxicity (LD50: > 7000 mg/kg bw).
Acute toxicity: inhalation
Classified under Annex I of Directive 67/548/EEC with R23 (toxic by inhalation). This classification corresponds to Category 3* (minimum classification: toxic if inhaled) according to Annex VI-1 of Regulation (EC) No 1272/2008. Differing from this the LC50 value of 124 mg/m3 (vapour) for rats leads to the following classification according to Annex I of Regulation (EC) No 1272/2008: Category 1 (H330: Fatal if inhaled as vapour).
Classification of acute inhalation toxicity with regard to Specific Target Organ Toxicity - Single Exposure (STOT-SE):
Due to respiratory irritation effects HDI was classified under Annex I of Directive 67/548/EEC with R37 (irritating to respiratory system). This classification corresponds to STOT-SE Category 3 (H335: May cause respiratory irritation) according to Annex VI-1 of Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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