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EC number: 236-671-3 | CAS number: 13463-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD and EU guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.21 (Soil Microorganisms: Nitrogen Transformation Test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Toxi-Coop ZRT.
Test material
- Reference substance name:
- Pyrithione zinc
- EC Number:
- 236-671-3
- EC Name:
- Pyrithione zinc
- Cas Number:
- 13463-41-7
- Molecular formula:
- C10H8N2O2S2Zn
- IUPAC Name:
- Bis [1-hydroxy-2(1H)-pyridinethionato-O,S](T-4)-zinc
- Details on test material:
- - Name of test material: Zinc pyrithione
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable.
Sampling and analysis
- Analytical monitoring:
- not required
- Details on sampling:
- Not applicable.
Test substrate
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- The test item was applied using fine quartz sand (particle size: more than 40 % 0.2-0.8 mm) as carrier. For an optimum distribution of the test item in the soil, a ratio of 10 g of sand per kilogram of soil (dry weight) was used. A homogeneous distribution of the test item in the artificial soil was obtained by thorough mixing.
Study design
- Total exposure duration:
- 28 d
Test conditions
- Test temperature:
- 20 ± 2 °C
- Moisture:
- 40 % to 60 % of the maximum water holding capacity (WHC) of the soil with a range of ± 5 % during the test
- Details on test conditions:
- TEST SYSTEM
- Testing facility: TOXI-COOP ZRT.
- Test container (type, material, size): Erlenmeyer glass flasks of 250 cm3
- Amount of soil: 20 g dry soil weight
- No. of replicates per concentration: 6
- No. of replicates per vehicle control: 6
SOIL INCUBATION
- Method: series of individual subsamples
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Geographical reference of sampling site (latitude, longitude): Hungary (GPSX: 45º51’36”; GPSY: 17º58’03”)
- History of site: The site chosen for soil collection was used as arable land until 2010 with cereals as the last culture grown.
- Vegetation cover: In the year 2011, it was planted with 3-year old oak plants and used as a forest since then.
- Treatments with pesticides or fertilizers: The area had not been treated with crop protection products, organic or mineral fertilizer for at least 3 years before sampling.
- Accidental contamination: None
- Other: None
- Depth of sampling: 25 cm
- Soil texture
- % sand: 59.30
- % silt: 25.50
- % clay: 15.30
- Soil taxonomic classification: Sandy loam
- Soil classification system: USDA classification system
- pH (in water): 5.65
- Initial nitrate concentration for nitrogen transformation test (mg nitrate/kg dry weight): 63.0 mg/100 g
- Maximum water holding capacity (in % dry weigth): 18.9 g/100 g soil dw
- Cation exchange capacity (mmol/kg): 130.4 mmol/kg
- Pretreatment of soil: None
- Storage (condition, duration): The soil was stored in refrigerator for 24 days and pre-incubated under test conditions for 10 days in the dark under aerobic conditions.
- Initial microbial biomass as % of total organic C: 9.42
DETAILS OF PREINCUBATION OF SOIL (if any): None
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
VEHICLE CONTROL PERFORMED: yes
RANGE-FINDING STUDY
- Test concentrations: 0.1 - 1000 mg/kg soil dw
- Results used to determine the conditions for the definitive study: yes - Nominal and measured concentrations:
- Not applicable.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 10.24 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- nitrate formation rate
- Duration:
- 28 d
- Dose descriptor:
- EC10
- Effect conc.:
- 10.35 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- nitrate formation rate
- Remarks on result:
- other: 7.12 – 15.06
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 89.68 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- nitrate formation rate
- Remarks on result:
- other: 73.77 –109.02
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- The coefficient of variation in nitrate content between replicate control samples was less than ± 15% at each observation time, i.e. 6.3 % on day 0 and 3.6 % on day 28. Therefore, the study is considered to be valid.
- Conclusions:
- In a laboratory study with the test item effects on nitrogen transformation processes in soil were determined: EC10 = 10.35 mg/kg dw (95 % confidence intervals: 7.12 – 15.06 mg/kg dw); EC50 = 89.68 mg/kg dw (95 % confidence intervals: 73.77 –109.02 mg/kg dw). The overall NOEC was determined to be 10.24 mg/kg dw while the overall LOEC was determined to be 25.6 mg/kg dw.
The information contained within this robust summary document comes from studies which are in the ownership of Lonza Ltd. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Lonza Ltd. under Regulation EC 1907/2006.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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