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EC number: 215-578-1 | CAS number: 1333-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 April 1986 - 06 May 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed under GLP and according to internationally accepted guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Toluenesulphonamide
- EC Number:
- 215-578-1
- EC Name:
- Toluenesulphonamide
- Cas Number:
- 1333-07-9
- Molecular formula:
- C7H9NO2S
- IUPAC Name:
- methylbenzenesulfonamide
- Reference substance name:
- Toluenesulphonamide (o/p-TSA)
- IUPAC Name:
- Toluenesulphonamide (o/p-TSA)
- Test material form:
- solid: flakes
- Details on test material:
- - Trade name/code: Ketjenflex-9
- Batch no.: PA 20/1/86
- Appearance: Fl akes
- Purity: Mixture of toluene sulfonamides (o/m/p= 41/8/51); water content 0.35%, sulphate content= 135 ppm
- Solubility: Insoluble in water
- Stability: Stable
- Storage: At ambient temperature in the dark
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa-Credo, Brussels, Belgium
- Age at study initiation: no data, young.
- Weight at study initiation: The body weights of the males on day 0 ranged from 354 to 435 those of the females from 225 to 273 g.
- Fasting period before study: Feed was withheld overnight before dosing till approximately 4 hours after administration of the test substance.
- Housing: Four days prior to dosing the animals were individually housed in polycarbonate cages.
- Diet (e.g. ad libitum): ad libitum, standard laboratory animal diet (RMH-By pellet diameter 10 mm), which was obtained from Hope Farms, Woerden, The Netherlands.
- Water (e.g. ad libitum): ad libitum, tap-water
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-23
- Humidity (%): 40-80
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 14 April 1986 - 06 May 1986
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: details not provided
- Amount of vehicle (if gavage): Fixed volume for all concentrations in ml/kg; does not exceed 10 ml/kg
- Justification for choice of vehicle: details not provided
- Lot/batch no. (if required): details not provided
- Purity: details not provided
MAXIMUM DOSE VOLUME APPLIED: does not exceed 10 ml/kg
DOSAGE PREPARATION (if unusual): no data - Doses:
- 1800, 2100, 2400 mg/kg bw day
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals are observed for a period of 14 days, i .e. every two hours on the day of administration of the test substance and once every day thereafter. Individual body weights of the animals are determined on the day of dosing, weekly thereafter and at death.
- Necropsy of survivors performed: yes
- Other examinations performed: none - Statistics:
- The LD50 value, where possible a seperate value for males and females, is calculated from the observed mortality data, using any established statistical procedure, e.g. that of Litchfield and Wilcoxon (l949), Weil (1952) or Finney (1971).
Results and discussion
- Preliminary study:
- Based on literature data on the LD50 values of the separate components of the test substance and the LD50 value of a related substance as provided
by the sponsor, three dose levels were selected: 1800, 2400 and 3200 mg/kg body weight. However, the highest dose presented a too viscose suspension that could not be adequately administered as one single dose. It was therefore decided to select one dose level in between 1800 and 2400 mg/kg, namely 2100 mg/kg.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 400 mg/kg bw
- Mortality:
- Only in the high dose group 5 out of 10 animals died. There was no evident sex related effect. One female animal of the mid dose group had received only approximately 25% of its dose due to clogging of the test material in the dosing cannula. However this is not considered to have affected the outcome of this study, since no mortality was found in this treatment group. All deaths occurred within 3 days of dosing.
- Clinical signs:
- other: Major signs of toxicity were lethargy, unbalanced gait, dyspnea for the mid and low dose groups, and for the high dose group in addition to the afore mentioned symptoms, coma, bloody eye encrustation, absent or bloody stool and slimy salivation. All anima
- Gross pathology:
- Macroscopic examination of animals found dead generally revealed test substance related petechiae and/or haemorrhages of the stomach frequently combined with bloody intestinal content and marked haematuria. One male of the high dose group revealed an atrofic testis, which was not considered to be test substance related. Macroscopic examination of surviving animals at the end of the study showed no test substance related gross abnormalities.
Any other information on results incl. tables
Mortality:
Sex |
Dose (mg/kg) |
# deaths |
Total # animals |
Day 1 |
Day 2 |
Day 3 |
Day 4-15 |
1800 |
0 |
5 |
0 |
0 |
0 |
0 |
|
M |
2100 |
0 |
5 |
0 |
0 |
0 |
0 |
2400 |
2 |
5 |
0 |
1 |
1 |
0 |
|
1800 |
0 |
5 |
0 |
0 |
0 |
0 |
|
F |
2100 |
0 |
5 |
0 |
0 |
0 |
0 |
2400 |
3 |
5 |
2 |
1 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The LD50 value for the sexes combined was estimated to be approximately 2400 mg/kg body weight.
- Executive summary:
According to OECD401 and under GLP an acute oral toxicty study was performed with o/p-TSA. Three groups of Wistar rats, each comprising 5 males and 5 females, received a single oral dose of o/p-TSA at 1800, 2100 and 2400 mg/kg body weight, respectively. Only in the high dose group 5 out of 10 animals died. There was no evident sex related effect. All deaths occurred within 3 days of dosing. Major signs of toxicity were lethargy, ataxia and dyspnea for surviving animals, whereas for dead animals also coma was observed. For surviving animals these signs were reversible since as of day 4 no more abnormalities were observed during the 14-day observation period. Macroscopic examination of animal s found dead generally revealed test substance related petechiae and/or haemorrhages of the stomach frequently accompanied by bloody intestinal content and marked haematuria. Macroscopic examination of surviving animals at autopsy revealed no treatment related gross abnormalities. The LD50 value for the sexes combined was estimated to be approximately 2400 mg/kg body weight.
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