Registration Dossier
Registration Dossier
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EC number: 215-578-1 | CAS number: 1333-07-9
Endpoint summary
Administrative data
Description of key information
Additional information
op-TSA is assumed to be hydrolytically stable from a guideline study with o-TSA.
A SCAS test, valid with restrictions, is available. During the twenty-one day biodegradation phase of the study op-TSA was 92.9% biodegraded when initially present at 56.9 ppm. The test material is considered to undergo rapid primary biodegradation based upon this study. Examination of the microbial population data shows no evidence of adverse effects of the test compound upon the microflora present in the sludge.
op-TSA is inherently biodegradable.
o/p-TSA has a low log Kow and is highly soluble in water, therefore adsorption to soil and sediment is not expected to take place. Therefore, biodegradation in soil and sediment as well as an adsorption/desorption studie are waived.
Bioaccumulation studies with o-TSA and p-TSA gave the following results:
A study with o-TSA was performed according to OECD guideline 305C with Cyprinus carpio at 0.3 and 3 mg/L. After 42 days the BCF vaues were 0.4 to 0.9 at 3 mg/L and < 2.6 at 0.3 mg/L. This shows that o-TSA does not have a potential to bioaccumulate.
A study for p-TSA with Oncorhynchus mykiss was performed with Chloramine-T (CAS 127 -65 -1). As p-TSA was detected and actually BCF values were calculated for p-TSA, this study can be used for p-TSA.
The kinetic whole body BCF as calculated from the accumulation and depuration from fingerling half-lives using the p-TSA equivalent concentration (worst-case). The k1/k2 ratio as calculated according to OECD guideline 305 is 2.2 based on LSC (worst case).
As op-TSA is a mixture of o-TSA and p-TSA it can be concluded that op-TSA does not have a potential to bioaccumulate either.
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