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Diss Factsheets
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EC number: 236-921-1 | CAS number: 13548-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
According to Chapter R.7a: Endpoint specific guidance, table R.7.7-5, row 9, no further tests are required since available data ( results from in vitro gene mutation in bacteria and cytogenicity study in vitro and in vivo) is sufficient to conclude that test article is non-mutagenic.
In bacterial tests, chromic nitrate compounds have shown mainly negative results. De Flora et al. (1990) summarized the results of 11 studies on chromium(III) nitrate. The assays included various types of tests with Escherichia coli, Salmonella typhimurium, and Bacillus subtilis with and without metabolic activation systems. With few exceptions contaminated with Cr (VI), these studies showed negative results. Positive doses were generally very high. One Ames test study on gene mutation by chromic nitrate in S. typhimurium was also negative (Venier et al, 1982)
In old studies in cultured mammalian cells, chromic nitrate gave negative effect when tested for chromosomal aberrations with human lymphocytes (Nakamuro et al., 1978). In addition, Venier et al. (1982) observed that chromic nitrate cannot increase in SCEs and chromosomal aberration used as parameters of clastogenicity in Chinese hamster ovary cells when the incubation time was 30 h to cover two division cycles, unless contaminated by Cr (VI) compounds. The results summarized in another report published by Bianchi V et al. supported the conclusion as discussed above.
In the report published by De Flora et al. (1990), summarized that chromic nitrate produced negative response in in vivo micronuclei assay conducted with mouse.
Short description of key information:
Based on the available data, chromic nitrate showed mainly negative results in bacterial assay and cultured mammalian cells, with few exception contaminated with Cr (VI).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results as discussed, chromium trinitrate showed negative mutagenic results, thus, it does not require classification according to CLP (Regulation EC No. 1272/2008) or DSD (Directive 67/548/EEC).
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