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EC number: 247-955-1 | CAS number: 26748-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-10-05 to 2011-11-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- adopted 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- adopted 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus:
HPLC system 2: Merck-Hitachi LaChrom Elite
L-2000 Organizer, No.: 22E82-042
L-2130 HPLC pump, No.: 22E50-029
L-2200 Autosampler, No.: 22E81-005
L-2400 UV Detector, No.: 22E80-018
L-2350 Column Oven, No.: 2274-034
Balance: BL120S Sartorius, No.: 15307011
Ultrasonic bath: Branson 3210, No.: A700343D
Water purification system: MILLIPORE, DIRECT Q5,
No.: FODA13956K
- HPLC Conditions:
Column: LiChrospher 100 CN (5μm) 250x4, No: 933278
Mobile Phase: Acetonitrile : water =60 : 40 (v/v)
Flow: 0.8 mL/min
Injection volume: 10 μl
Temperature: 25 °C
Detector: 254 nm (Reference standards)
Detector: 210 nm (TBPND)
DETERMINATION OF DEAD TIME
- Method: by means of homologous series / by inert substances which are not retained by the column
REFERENCE SUBSTANCES
- Identity: Sodium nitrate, Acetanilide, Methyl Benzoate, Naphthalene, Fenthion, Pyrazophos, Phenanthrene, DDT
DETERMINATION OF RETENTION TIMES
Three series of the above-mentioned reference solutions were measured with two parallel injections, each. Three series of the test item solution were measured with two parallel injections, each. The retention times were determined. The three calibration series and three test item series were measured alternately. For the determination of t0 (t0 = retention time of the unretarded component) three series of Sodium Nitrate solution were injected two times.
EVALUATION
Chromatograms were evaluated using EZChrom Elite chromatogram processor software. Calculations were carried out using Microsoft Office Excel.
The capacity factors, k were calculated from the retention times (tR) of the selected reference substances and the dead time (t0):
k = (tR-t0)/t0
Then the log k data of the reference substances were plotted against their log Koc values. The regression coefficients (a, b) were determined by linear
regression calculation using the least squares method. The log Koc value of the test item was calculated, using these regression coefficients and the capacity factor of the test item: log k = a + b*log Koc
where: Koc = adsorption coefficient; a = constant; b = slope; k = capacity factor - Key result
- Type:
- Koc
- Value:
- 4 424
- Temp.:
- 25 °C
- Remarks on result:
- other: Conf.int.(95%) 538
- Key result
- Type:
- log Koc
- Value:
- 3.64
- Temp.:
- 25 °C
- Remarks on result:
- other: Conf.int.(95%) 0.052
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration:
Naphthalene: 4.92 min
Fenthion: 5.30 min
Pyrazophos: 5.00 min
Phenantrene: 5.44 min
DDT: 7.07 min
- Details of fitted regression line (log k' vs. log Koc): The correlation coefficient R for the relationship between log k' and log Koc of the test substance is 0.949. - Validity criteria fulfilled:
- yes
- Conclusions:
- The determined log Koc: 3.64 ± 0.052 (95 % confidence interval). The determined Koc: 4424 ±538 (95 % confidence interval).
- Executive summary:
The purpose of this study was to estimate the adsorption coefficient, Koc of the test item using HPLC. This method is applicable for substances, which have log Koc value ranging from 1.5 to 5.0. The adorption coefficient was estimated to be 4424 and the log Koc was 3.64.
Reference
Description of key information
The adsorption coefficient of the test item was assessed according to OECD guideline 121 and EU-method C.19.The log Koc was determined to be 3.64.
Key value for chemical safety assessment
- Koc at 20 °C:
- 4 424
Additional information
The Koc was measured using the HPLC method. This method is applicable for substances which have log Koc value ranging from 1.5 to 5.0. The adorption coefficient was estimated to be 4424 and the log Koc was 3.64.
[LogKoc: 3.64]
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