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Diss Factsheets
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EC number: 209-400-1 | CAS number: 576-26-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted in methods comparable to OECD guideline 401. However, animal acclimation information was not provided. Animals were only fasted for 3-4 hours before dosing. Body weight results are not provided in the report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Animal acclimation information was not provided. Animals were only fasted for 3-4 hours before dosing. Body weight results are not provided in the report.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,6 xylenol
- IUPAC Name:
- 2,6 xylenol
- Reference substance name:
- 2,6-xylenol
- EC Number:
- 209-400-1
- EC Name:
- 2,6-xylenol
- Cas Number:
- 576-26-1
- Molecular formula:
- C8H10O
- IUPAC Name:
- 2,6-dimethylphenol
- Details on test material:
- - Name of test material (as cited in study report): 2,6-xylenol (2,6-dimethylphenol)
- Physical state: white solid
- Analytical purity: The material was considered to be free of impurities.
- Other: received on February 25, 1965. The test substance has a strong pungent odor.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 207 to 326 grams
- Fasting period before study: Food was withheld from the animals for a period of three to four hours prior to dosing.
- Housing: Following intubation, the animals were housed by groups in metal cages.
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10 or 20% weight/volume solution - Doses:
- 100, 215, 464, 1000, 2150, and 4640 mg/kg bw
- No. of animals per sex per dose:
- five
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: Animals were closely observed for mortality and toxic effects at the following intervals after compound administration: immediately; at one, four, and 24 hours; and once daily thereafter for a total of 14 days. At the end of the observation period, the surviving animals were weighed, sacrificed by cerebral concussion, and necropsied.
- Necropsy of survivors performed: yes. At the end of the observation period, the surviving animals were weighed, sacrificed by cerebral concussion, and necropsied. Necropsies were also performed on the animals that succumbed during the course of the study.
- Other examinations performed: clinical signs - Statistics:
- Statistical analysis of the mortality data was conducted by the method by Thompson, W.R., Bact. Rev., 11, 115, 1947, utilizing the tables of Horn, H. J., Biometrics, 12, 311, 1956.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 470 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals in the 100, 215, 464, and 1000 mg/kg bw dose groups survived the 14 day study period. In the 2150 mg/kg bw dose group, three animals died 1 hour after treatment, one animal died 24 hours after treatment, and one animal died 2 days after treatment. In the 4640 mg/kg dose group, all animals died 1 hour after treatment.
- Clinical signs:
- other: No clinical signs were observed in animals in the 100 mg/kg dose group. The principle clinical signs for animals in the 215, 464, and 1000 mg/kg bw groups were depression and flushed appearance, labored respiration and ataxia (1000 mg/kg dose level only)
- Gross pathology:
- No necropsy findings were observed in the 100, 215, 464, or 1000 mg/kg bw dose groups.
At the 2150 and 4640 mg/kg bw dose level, congestion of the lungs, liver, spleen, kidney, and adrenals; gastrointestinal inflammation and apparent sloughing of stomach mucosa were observed.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of 2,6-xylenol for adult male Sprague-Dawley rats is 1470 mg/kg body weight based on the results of this study.
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