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Diss Factsheets
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EC number: 202-710-8 | CAS number: 98-88-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient documentation, Klimisch 4.e study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
- Principles of method if other than guideline:
- The authors tested the eye irritation potential of benzoyl chloride by placing into the conjunctival sac of one eye 100 µL of the test substance of each rabbit. They followed the eye damages and signs of irritations.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzoyl chloride
- EC Number:
- 202-710-8
- EC Name:
- Benzoyl chloride
- Cas Number:
- 98-88-4
- Molecular formula:
- C7H5ClO
- IUPAC Name:
- benzoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): benzoyl chlorid
- Physical state: liquid
- Analytical purity: 99-100 %ig
- Lot/batch No.: 024042-20
- other:
Substance number: 027707-02
No further data available
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hacking & Churchill, huntingdon, England
- Weight at study initiation: 3-4 kg
- Housing: in standard cages
- Diet (e.g. ad libitum): Z 222 food from Höing Verden/Aller) ad libitum
- Water (e.g. ad libitum): ad libitum
No further data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 100 µL
- Duration of treatment / exposure:
- once
- Observation period (in vivo):
- Seven days
- Number of animals or in vitro replicates:
- Two
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing
SCORING SYSTEM: unknown
TOOL USED TO ASSESS SCORE: unknwon
No further data available
Results and discussion
In vivo
- Irritant / corrosive response data:
- Conjunctiva: severe redness, moderate to severe chemosis up to the end of the observation period;
Iris: slight to moderate swollen and hyperemic;
Cornea: slight diffuse opacity
No further data - Other effects:
- Strong lacrimation was observed throughout the overall duration of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- In the test conditions, the authors estimated the eye irritation potential of benzoyl chloride by exposing the conjonctival sac of rabbits eyes to 0.1 mL of the test substance. They estimated the substance was a strong irritant and corrosivefor the cornea after seven days of observation.
- Executive summary:
The authors estimated the eye irritation potential of benzoyl chloride by exposing conjonctival sac of New Zealand rabbits eyes to 0.1 mL of benzoyl chloride (CAS n° 98 -88 -4). They recorded eye damages and signs of irritation within a seven days post exposure observation period. Neither a scoring system is reported, nor criteria for interpretation of results.
By the end of the observation period, severe redness and moderate to severe chemosis of the conjonctivae, a slight to moderate swollen and hyperemic iris and a slight diffuse opacity of the cornea were observed . No scores are available for any of the parameters.
They concluded that benzoyl chloride is a strong irritant for eyes and corrosive for the cornea.
The GLP status of this study is unknwon as most of the details on materials and details. Results are insufficiently described as no scores are available, and neither a scoring system, nor criteria for interpretation of results are reported. Therefore, this study should be considered as not assignable due to insufficient documentation, a Klimisch 4.e study.
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