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Diss Factsheets
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EC number: 203-093-8 | CAS number: 103-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- N/A
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented, available information is sufficient for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl cinnamate
- EC Number:
- 203-093-8
- EC Name:
- Methyl cinnamate
- Cas Number:
- 103-26-4
- Molecular formula:
- C10H10O2
- IUPAC Name:
- methyl 3-phenylacrylate
- Test material form:
- solid: crystalline
- Details on test material:
- Chemical name Methyl cinnamate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- New Zealand white rabbits of both sexes (weighing 2.5 to 3.0 kg.) were used.
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The data obtained from acute oral LD50 studies in rats indicated relatively low toxicity of all test materials. Higher dosages were not used since LD50 values would have little meaning. Therefore, only one selected dose level of each compound was applied to a group of four rabbits of both sexes (weighing 2.5 to 3.0 kg). The dose site, approximately 240- cm2 (about 10% of body surface) was closely clipped. The skin of two of the animals was abraded and the skin of the two remaining animals was left intact. The skin was slightly moistened with physiological saline prior to application. Solid test materials were first ground to fine powders and then applied to the rabbit skin and covered with a nonabsorbent binder.
- Duration of exposure:
- 24 hr
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Animals were immobilized for 24 hours in stocks. Immediately following the removal of the binders, the local effects of the test compounds were scored according to the method of Draize. Toxic effects, dermal irritation, and mortality were recorded daily for 14 days. A necropsy was performed on each animal that died during the experiment and on those killed (by air embolism) at termination. Abnormal tissues and samples of adrenal, kidney, liver, lung, spleen, gonads, urinary bladder, bone, and skin were preserved in 10% formalin for possible histologic examination.
- Statistics:
- N/A
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No adverse effects were observed during the test.
- Mortality:
- There was no mortality observed with methyl cinnamate during the test.
- Clinical signs:
- other: All animals appeared to be normal throughout the entire 14-day observation period.
- Gross pathology:
- No gross pathologic findings occurred in the rabbit that were killed at termination.
- Other findings:
- N/A
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results given in this study, the dermal LD50 value is considered to be greater than 5000 mg/kg body weight.
- Executive summary:
This study was conducted to investigate the acute dermal toxicity of test substance. Rabbits were applied at dosage level of 5 g/kg body weight. There was no mortality of methyl cinnamate applied animals during the test. All animals appeared to be normal throughout the entire 14-day observation period. No gross pathologic findings occurred in the rabbit that were killed at termination. There was no skin irritation to either intact or abraded skin following treatment with test substance.
Therefore, test substance failed to cause acute dermal toxicity to rabbits during the test period.
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