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Diss Factsheets
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EC number: 207-306-5 | CAS number: 460-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 960
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Materials and methods
Four male albino rabbits whose weights averaged 4.5 pounds were closely clipped of their fur, restrained in a wooden stock, and placed in the chamber. An especially designed door, through which the rabbits heads extended into glass jarsmaintained under positive air pressure, prevented the rabbits from breathing cyanogen while their bodies were being exposed and also made observation of the heads of the rabbits possible. The bodies of the rabbits were exposed to ethanedinitrile concentration of 10,000 ppm for a period of 8 hours. - GLP compliance:
- no
Test material
- Reference substance name:
- Oxalonitrile
- EC Number:
- 207-306-5
- EC Name:
- Oxalonitrile
- Cas Number:
- 460-19-5
- Molecular formula:
- C2N2
- IUPAC Name:
- carbononitridic cyanide
- Test material form:
- gas
Constituent 1
- Specific details on test material used for the study:
- 99.5%
Test animals
- Species:
- rabbit
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Four male albino rabbits whose weights averaged 4.5 pounds were closely clipped of their fur, restrained in a wooden stock, and placed in the chamber. An especially designed door, through which the rabbits heads extended into glass jarsmaintained under positive air pressure, prevented the rabbits from breathing cyanogen while their bodies were being exposed and also made observation of the heads of the rabbits possible. The bodies of the rabbits were exposed to ethanedinitrile concentration of 10,000 ppm for a period of 8 hours.
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- other: air
- Details on exposure:
- 10,000 ppm (ca 21 g/m3) for 8 hours
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 8 hours
Doses / concentrations
- Dose / conc.:
- 10 000 other: ppm
- Remarks:
- ca 21 g/m3
- No. of animals per sex per dose:
- 4
- Details on study design:
- Four male albino rabbits whose weights averaged 4.5 pounds were closely clipped of their fur, restrained in a wooden stock, and placed in the chamber. An especially designed door, through which the rabbits heads extended into glass jarsmaintained under positive air pressure, prevented the rabbits from breathing cyanogen while their bodies were being exposed and also made observation of the heads of the rabbits possible. The bodies of the rabbits were exposed to ethanedinitrile concentration of 10,000 ppm for a period of 8 hours.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- no effects observed
- Mortality:
- no mortality observed
Effect levels
- Key result
- Dose descriptor:
- NOEL
- Effect level:
- 21 mg/cm² per day (nominal)
- Basis for effect level:
- clinical signs
- dermal irritation
Target system / organ toxicity
- Key result
- Critical effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- Dermal exposure of rabbits to ethanedinitrile gas in an acute toxicity study indicates that there is no intake of ethanedinitrile through skin. Dermal espousure of rabbits to 10,000 ppm (~21 g/m3) of ethanedinitrile for eight hours did not result in toxicity towards rabbits, or any clinical observations or macroscopic effects.
- Executive summary:
Materials and methods
Four male albino rabbits whose weights averaged 4.5 pounds were closely clipped of their fur, restrained in a wooden stock, and placed in the chamber. An especially designed door, through which the rabbits heads extended into glass jarsmaintained under positive air pressure, prevented the rabbits from breathing cyanogen while their bodies were being exposed and also made observation of the heads of the rabbits possible. The bodies of the rabbits were exposed to ethanedinitrile concentration of 10,000 ppm for a period of 8 hours.
Summary and conclusion
Dermal exposure of rabbits to ethanedinitrile gas in an acute toxicity study indicates that there is no intake of ethanedinitrile through skin. Dermal espousure of rabbits to 10,000 ppm (~21 g/m3) of ethanedinitrile for eight hours did not result in toxicity towards rabbits, or any clinical observations or macroscopic effects.
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