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Diss Factsheets
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EC number: 207-306-5 | CAS number: 460-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrogen cyanide vapours are absorbed through skin and mucous membranes surface. They are hazardous and toxic when inhaled but also when the skin is exposed.
Clinical picture of acute hydrogen cyanide poisoning: Superacute poisoning is the result of an unexpected high concentration of HCN, with unconsciousness occurring within only 10–20 seconds, followed by death in convulsions within 2–3 minutes. Acute poisoning symptoms include headache, dizziness, vision disorders, pressure in chest, rapid breathing and pulse, followed by asphyxiation and unconsciousness, and clonic and tonic convulsions, and finally respiratory and cardiac arrest. Mild poisoning symptoms include headache, dizziness, hearing problems, sore throat, and visual impairment and breathing problems. The patient is fully conscious and complete recovery is possible.
Clinical picture of chronic hydrogen cyanide poisoning: Chronic poisoning may result from repeated effects of small doses of hydrogen cyanide (cyanides) on organism for a longer time mostly due to regular consumption of food containing cyanogenic glycosides, or to repeated occupational exposures. Persons regularly exposed to effects of HCN have an increased red blood cells count, hypothyreosis as well as neurologically detected changes.
Acute toxic levels and doses: The dose-effect curve of the acute effects in humans is steep. Whereas slight effects occur at exposure to hydrogen cyanide levels of 20–40 mg/m3, 50–60 mg/m3 can be tolerated without immediate or late effects for 20 min to 1 h, 120–150 mg/m3 is dangerous to life and may lead to death after 0.5–1 h, 150 mg/m3 is likely to be fatal within 30 min, 200 mg/m3 is likely to be fatal after 10 min, and 300 mg/m3 is immediately fatal.
Effective and no-effect levels for chronic exposures: Workers exposed to HCN concentrations 17 mg/m3 revealed a high prevalence of neurological, cardiovascular and gastrointestinal symptoms; after exposure to 5–13 mg/m3 for seven years showed in a large extent of subjective symptoms (headache, weakness, ao).
No epidemiological studies have been performed on ethanedinitrile. No evidence of human sensitisation was found in literature and observed in workers.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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