Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-494-1 | CAS number: 530-78-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No internal ADME studies were conducted with Flufenamic acid.
Results of a dermal absorption and metabolism study with Flufenamic acid in rats were found in literature (Nov 2011):
After dermal application of 14C-flufenamic acid ointment radioactivity was detected in the skin at the site of application up to 72 h after application (predominantely at a depth of 200 -400 µm, decreasing concentrations at a depth of 400 -1600 µm) and in the blood. The test item was not metabolised but remained unchanged.
(Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- v.24, p. 691, 1982 (OYYAA2))
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
