Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-216-8 | CAS number: 7790-62-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labelling and/or risk assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII.
- Author:
- Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, and Nycum JS
- Year:
- 1 969
- Bibliographic source:
- Hyg. Assoc. J., 30(5):470-476
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VI
- Author:
- Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, and Striegel JA
- Year:
- 1 962
- Bibliographic source:
- Amer. Ind. Hyg. Assoc. J., 23:92
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Remarks:
- The study was conducted according to the guideline in effect dated 2001.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Sulphuric acid
- EC Number:
- 231-639-5
- EC Name:
- Sulphuric acid
- Cas Number:
- 7664-93-9
- IUPAC Name:
- sulfuric acid
- Details on test material:
- - Purity: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4-5 weeks of age
- Weight at study initiation: 90-120 grams
- Fasting period before study: no
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.250 g/mL - Doses:
- - The doses were arranged in a logarithmic series differing by a factor of two.
- Concentration in vehicle: 0.250 g/mL - No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 140 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 1540-2990 mg/kg
Applicant's summary and conclusion
- Conclusions:
- This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
LD50 = 2140 mg/kg - Executive summary:
An acute oral toxicity study with the test substance on groups of 5 rats reported an LD50 of 2140 mg/kg/body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
