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Diss Factsheets
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EC number: 203-500-9 | CAS number: 107-54-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Methyl pentynol is a structural analogon to the to be registered substance. Justification for read across is perfectly provided in the document "Screening-Level Hazard Characterization and Prioritization Document on ALPHA HYDROXY ALKYNES CLUSTER - 4 Chemicals" prepared by EPA in 2009. This document is attached at this endpoint of this dossier.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Section 1500.41, - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38, No. 187, P. 27019, 27 September 1973.
- Deviations:
- not specified
- Principles of method if other than guideline:
- In carrying out the study the experimental sample was used as supplied. A group o f six albino rabbits were clipped over a wide area. One side o f the animals' backs was abraded at one site with a lancet sufficiently deep to penetrate the stratum corneum but not enter the derma to produce bleeding.
The skin of the other side was allowed to remain intact. A 0.5 ml portion of material was applied to an abraded and an intact skin site on the same rabbit.
Gauze patches were then placed over the treated areas and an impervious material was wrapped snugly around the trunks of the animals to hold the patches in place.
The wrapping was removed at the end o f the twenty-four hour period and the treated areas were examined. Readings were also made after seventy-two hours. The Draize method of scoring was employed. - GLP compliance:
- no
Test material
- Reference substance name:
- Methylpentynol
- EC Number:
- 201-055-5
- EC Name:
- Methylpentynol
- Cas Number:
- 77-75-8
- IUPAC Name:
- 3-methylpent-1-yn-3-ol
- Reference substance name:
- 3-Methyl-1-pentyn-3-ol
- IUPAC Name:
- 3-Methyl-1-pentyn-3-ol
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6 rabbits
Results and discussion
Any other information on results incl. tables
Reading (Hours) | Rabbit Number | |||||||||
Erythema and Eschar Formation | 1 | 2 | 3 | 4 | 5 | 6 | Average | |||
Intact Skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Intact Skin | 72 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Abraded Skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Abraded Skin | 72 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Subtotal | 4.0 | |||||||||
Reading (Hours) | Rabbit Number | |||||||||
Edema Formation | 1 | 2 | 3 | 4 | 5 | 6 | Average | |||
Intact Skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Intact Skin | 72 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | ||
Abraded Skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Abraded Skin | 72 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | ||
Subtotal | 2.0 | |||||||||
Total | 6.0 | |||||||||
Primary Irritation Score:
6.0 / 4 = 1.5
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Section 1500.41, - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38, No. 187, P. 27019, 27 September 1973.
- Conclusions:
- Based on the accompanying table, the subject material would not be classified as a primary irritant to albino rabbits within the definition of the Act-Reference: Section 1500.3 (c) (4) and requires no cautionary labeling with respect to that section.
Primary Irritation Score:
6.0 / 4 = 1.5 - Executive summary:
Based on the accompanying table, the subject material would not be classified as a primary irritant to albino rabbits within the definition of the Act-Reference: Section 1500.3 (c) (4) and requires no cautionary labeling with respect to that section.
Primary Irritation Score:
6.0 / 4 = 1.5
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