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EC number: 203-500-9 | CAS number: 107-54-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test done before GLP and Guidelines were established.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1175 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 3,5-dimethylhex-1-yn-3-ol
- EC Number:
- 203-500-9
- EC Name:
- 3,5-dimethylhex-1-yn-3-ol
- Cas Number:
- 107-54-0
- Molecular formula:
- C8H14O
- IUPAC Name:
- 3,5-dimethylhex-1-yn-3-ol
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The outbred Sprague-Dawley rat, weighing 202 to 283 grams, was used for this study. The animals were obtained from Buckshire Corp., Perkasie, PA 18944 (U.S.D.A. License #23-BL) and were nulliparous and non-pregnant.
The animals were housed and maintained in accordance with standards set forth in the Guide for the Care and Use of Laboratory Animals (NIH Publication No. 86-23). The rats were acclimated to the laboratory for at least 5 days prior to dosing and the weight variation did not exceed +/- 20% of the mean weight for each sex.
The animals were individually identified by an ear punch. Each cage was identified with a cage card, displaying the project number, animal
number, sex, date dosed, dose level and responsible technician's initials.
Temperature: 18°C - 26°C (64.4°F - 78.8°F)
Relative Humidity, %: 40 - 70
Light: 12-hour lightldark cycle
Diet: Wayne Rodent-Blox and tap water were provided gd libitum. Based on our current knowledge, no contaminants are known to be in this diet or water which might be expected to interfere with the objectives of the study.
Caging: Stainless steel elevated wire mesh flooring, 5 ratslcage by sex.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test article was administered as supplied, at a dose level of 200 mg/kg.
One group of ten (5 male & 5 female) albino rats was deprived of food but not water overnight prior to dosing. Each animal was weighed and dosed by direct administration of the test article into the stomach by gavage.
Following administration, the animals were allowed food and water ad libitum for the 14-day observation period during which time, the rats were observed for signs of toxicity and mortality. Animals were observed frequently on the day of dosing. A careful clinical examination was performed at least once each day (7 dayslweek). On weekdays, a second observation of mortalitylmoribundity was performed.
Individual weights were recorded on the day of dosing, weekly thereafter, and prior to sacrifice. The animals were euthanized using carbon dioxide at the conclusion of the observation period. Gross necropsies were performed on all animals. - Doses:
- 200 mg/kg
- No. of animals per sex per dose:
- 5 mal and 5 female
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Gross pathology:
- Gross Pathology:
Males
No gross abnormalities were observed for the animals necropsied at the conclusion of the 14-day observation period.
Females
No gross abnormalities were observed for the animals necropsied at the conclusion of the 14-day observation period. - Other findings:
- Observations:
Males
Immediate - 5/5 animals appeared normal.
1 hour - 5/5 animals appeared lethargic.
4 hours - 5/5 animals appeared normal.
Day 1 - 1/5 exhibited audible respiration (gasping);
4/5 animals appeared normal.
Day 2-Day 14 - 5/5 animals appeared normal.
Females
Immediate - 5/5 animals appeared normal.
1 hour - 5/5 animals appeared lethargic.
4 hours - 5/5 animals appeared normal.
Day 1 - 1/5 animals exhibited vocalization,
4/5 animals appeared normal.
Day 2-Day 14 - 5/5 animals appeared normal.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test article, when administered as supplied to 5 male and 5 female albino rats, appears to have an acute oral LD50 greater than 200 mg/kg.
Based on the results outlined in this study and considering the 1972 study, the LD0 is 200 mg/kg bw and it is believed that the LD50 is >300 mg/kg bw. - Executive summary:
The test article, when administered as supplied to 5 male and 5 female albino rats, appears to have an acute oral LD50 greater than 200 mg/kg.
Based on the results outlined in this study and considering the 1972 study, the LD0 is 200 mg/kg bw and it is believed that the LD50 is >300 mg/kg bw.
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