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EC number: 700-742-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August- September 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- The observation period should be up to 14 days after administration (in the present study the last observation was done at 72 hours after administration).
- GLP compliance:
- no
- Remarks:
- The sudy was performed prior to the adoption of the GLP compliance
Test material
- Reference substance name:
- Diallyl 2,2'-oxydiethyl dicarbonate
- EC Number:
- 205-528-7
- EC Name:
- Diallyl 2,2'-oxydiethyl dicarbonate
- Cas Number:
- 142-22-3
- Molecular formula:
- C12H18O7
- IUPAC Name:
- diallyl 2,2'-oxydiethyl dicarbonate
- Details on test material:
- - Substance type: organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: data not available
- Age at study initiation: data not available
- Weight at study initiation: data not available
- Housing:data not available
- Diet (e.g. ad libitum): data not available
- Water (e.g. ad libitum):data not available
- Acclimation period:data not available
ENVIRONMENTAL CONDITIONS
data not available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: one test site was abraded, the other one remained intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL undiluted
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 and 72 hours after administration
- Number of animals:
- 4
- Details on study design:
- The test procedure was modeled after that of Draize et al. Prior to the application of the test material, the hair was clipped from the back and flanks of each rabbit.
TEST SITE
- Area of exposure: Two test sites located lateral to the midline of the back approximately ten centimeters apart were selected.
- % coverage: no data
The test material was applied to each of the test sites on each rabbit.
- Type of wrap if used: The test sites were immediately occluded with two-inch square gauze patches. The patches were placed directly over the test sites and secured with masking tape. The trunk' of each animal was then wrapped with impervious plastic sheeting. The wrap held the patches in position and retarded evaporation of the test material during the 24-hour exposure period. To prevent ingestion, a light-weight collar was placed on each animal.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
- Time after start of exposure: 24 hours
The intact and abraded test sites were examined and scored separately for erythema and edema on a graded scale of 0 to 4. After 72 hours, the sites were reexamined and rescored. In evaluating the average irritation present, the mean scores for erythema and edema of the intact lest sites after 24 and 72 hours were added. Similarly, the mean scores for erythema and edema of the abraded test sites after 24 and 72 hours were added. These two values were totaled and divided by four to obtain the mean primary irritation score.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3.5
- Time point:
- other: 24 hours
- Score:
- 2 - 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: abraded skin sites
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3.5
- Time point:
- other: 72 hours
- Score:
- 2 - 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: abraded skin sites
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3.5
- Time point:
- other: 24 hours
- Score:
- 2 - 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: abraded skin sites
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3.2
- Time point:
- other: 72 hours
- Score:
- 1 - 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: abraded skin sites
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3.5
- Time point:
- other: 24 hours
- Score:
- 2 - 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: intact skin sites
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3.5
- Time point:
- other: 72 hours
- Score:
- 2 - 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: intact skin sites
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3.5
- Time point:
- other: 24 hours
- Score:
- 2 - 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: intact skin sites
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3.2
- Time point:
- other: 72 hours
- Score:
- 1 - 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: intact skin sites
- Irritant / corrosive response data:
- no data
- Other effects:
- not known
Any other information on results incl. tables
Table 3: Results of Primary Skin Irritation Test (Report Date: 10 September 1971)
TEST MATERIAL: 'diallyl 2,2'oxydiethyl dicarbonate' |
||||||||
Primary Skin Irritation Test - Albino Rabbits |
||||||||
Results |
||||||||
Animal Number |
Irritation Scores for Abraded Skin Sites At: |
Irritation Scores for Intact Skin Sites At: |
||||||
24 Hours |
72 Hours |
24 Hours |
72 Hours |
|||||
Er. |
Ed. |
Er. |
Ed. |
Er. |
Ed. |
Er. |
Ed. |
|
1 |
4 |
4* |
4 |
4* |
4 |
4* |
4 |
4* |
2 |
2 |
2 |
2 |
1 |
2 |
2 |
2 |
1 |
3 |
4 |
4** |
4 |
4** |
4 |
4** |
4 |
4** |
4 |
4 |
4** |
4 |
4** |
4 |
4** |
4 |
4** |
Mean |
3.5 |
3. 5 |
3. 5 |
3. 2 |
3.5 |
3. 5 |
3. 5 |
3. 2 |
Subtotal |
13. 7 |
13. 7 |
||||||
Primary Irritation Score = 6.8 |
|
Key: Er. = Erythema Ed, = Edema * Subdermal hemorrhage ** Superficial burns
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- In 3/4 rabbits, both abraded and non-abraded sites had scores of 4 for both erythema and edema at 24 and 72 hours (beet or crimson red erythema and swelling of more than 1 mm). Superficial burns were noted in 2 of these animals at both time points. Erythema and edema were not as severe in one animal (scores of 2 and 1). The average primary irritation score was 6.8 (extremely irritating).
- Executive summary:
Undiluted test material (0.5 mL) was applied to one intact and one abraded skin site on four rabbits under occluded conditions for 24 hours and assessed for up to 72 hours after exposure. In three of the four rabbits, both abraded and non-abraded sites showed severe erythema and edema at 24 and 72 hours. Carbonic acid, oxydiethylene diallyl ester was highly irritating to rabbit skin.
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