Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 692-448-4 | CAS number: 170621-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 - 16 Mar 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- adopted 13 Apr 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- adopted 31 May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Version / remarks:
- June 1996
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Rheinland-Pfalz, Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht, Mainz, Germany
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: All concentrations were sampled
- Sampling method: Samples were collected at test start, at test end and at medium renewal from the old and new media. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: As the water solubility of the test item lies below 1 mg/L, the test solution was prepared by adding the appropriate test item to 1 liter of dilution water. After shaking vigorously for 24 hours the resulting solution was filtrated through 0.45 µm filters. Following this, the filtrates were used for the main test without dilution. Each treatment concentration was prepared separately and split into four aliquots for each replicate respectively. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Source: Laboratory culture, originally obtained from Umweltbundesamt Berlin, Germany, on 27 Sep 2007
- Age at study initiation (mean and range, SD): < 24 h
- Method of breeding: According to ISO 6341, animals multiply by parthenogenesis
- Feeding during test: None
CULTURE CONDITIONS
- Vessels: 2 L preserving glasses
- Medium: M4 medium
- Medium renewal: twice a week
- Type and amount of food: unicellular green algae (Desmodesmus subspicatus)
- Light and temperature: 16h light/8 h dark using neon tubes, 20 ± 2 °C - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 21.3 - 23.6 °C
- pH:
- 7.4 - 8.7
- Dissolved oxygen:
- 7.9 - 8.6 mg/L
- Nominal and measured concentrations:
- 0, 10, 18, 32, 56 and 100 mg/L (nominal, loading rate)
- Details on test conditions:
- TEST SYSTEM
- Material, size, fill volume: Glass beakers, 50 mL nominal, filled with 20 ± 5 mL
- Renewal rate of test solution (frequency/flow rate): after 24 h
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Deionised water was used to prepare ISO test water
- Culture medium different from test medium: no
- Intervals of water quality measurement: Dissolved oxygen and pH were measured at test start, at test end and at medium renewal in the old and new test media.
OTHER TEST CONDITIONS
- Adjustment of pH: yes (dilution water)
- Photoperiod: no lighting
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Immobilisation of daphnids was recorded 24 h and 48 h after test start.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- 15 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- loading rate
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: In the control, none of the Daphnia died or showed any signs of abnormal behaviour.
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50 (24h): 1.3 mg/L; accepted range: 0.6 - 1.7 mg/L
- Date of performance: 01 Mar - 02 Mar 2012
Reference
Table 1: Immobilisation of Daphnia magna after 24 and 48 h of exposure
Nominal concentration (mg/L) |
Immobility (%) |
|
24 h |
48 h |
|
0 |
0 |
0 |
10 |
0 |
10 |
18 |
50 |
75 |
32 |
75 |
100 |
56 |
90 |
100 |
100 |
90 |
100 |
Table 2: Analytical Determinations Al
The measured Al concentrations of each treatment and control as well as the geom. means for Al are given in the following table (Geometric mean is calculated by multiplication of the n participating concentrations and taking the nthroot):
Nominal Concentration in mg/L |
Measured Concentration of Al in mg/L |
% Recovery |
Measured Concentration of Al in mg/L |
% Recovery |
Geometric mean Al in mg/L |
||
0 h |
24h oM |
24h nM |
48 h |
||||
0 |
< LOQ |
< LOQ |
- |
< LOQ |
< LOQ |
- |
- |
10 |
0.23 |
0.14 |
60.63 |
0.22 |
0.16 |
75.15 |
0.18 |
18 |
0.43 |
0.23 |
52.67 |
0.3 |
0.21 |
69.15 |
0.28 |
32 |
0.76* |
0.32 |
41.79 |
0.4 |
0.28 |
69.81 |
0.40 |
56 |
1.10* |
0.4 |
36.64 |
0.09 |
0.08 |
87.15 |
0.24 |
100 |
1.16* |
0.39 |
33.29 |
0.65 |
0.3 |
45.43 |
0.54 |
LOQ = Limit of quantification (0.25 mg/L, corresponding to 0.025 mg/L based on a previous determination with tenfold enrichment)
oM = old Medium (before renewal)
nM = new Medium (after renewal)
*Without enrichment
Table 3: Analytical Determinations V
The measured Vanadium concentrations of each treatment and the control as well as the calculated geometric means for V are given in the following table. (Geometric mean is calculated by multiplication of the n participating concentrations and taking the nthroot):.
Nominal Concentration in mg/L |
Measured Concentration of V in mg/L |
% Recovery after 24 h |
Measured Concentration of V in mg/L |
% Recovery after 48 h |
Geometric mean V in mg/L |
||
0 h |
24h oM |
24h nM |
48 h |
||||
0 |
< LOQ |
< LOQ |
- |
< LOQ |
< LOQ |
- |
- |
10 |
0.05 |
0.03 |
72.44 |
0.04 |
0.04 |
113.25 |
0.04 |
18 |
0.08 |
0.06 |
71.82 |
0.06 |
0.06 |
105.37 |
0.06 |
32 |
0.12 |
0.09 |
77.85 |
0.08 |
0.09 |
111.4 |
0.09 |
56 |
0.15 |
0.11 |
71.49 |
0.06 |
0.06 |
110.04 |
0.09 |
100 |
0.16 |
0.11 |
70.28 |
0.16 |
0.15 |
92.1 |
0.14 |
LOQ = Limit of quantification (0.25 mg/L, corresponding to 0.025 mg/L in tenfold enrichment)
oM = old Medium (before renewal)
nM = new Medium (after renewal)
Description of key information
EL50 (48h, immobolisation) = 15 mg/L (nominal, loading rate)(OECD 202, Daphnia magna). Measured concentration of Al and V are 0.18 - 0.54 mg/L (geom. mean) and 0.04 - 0.14 mg/L (geom. mean)
, respectively.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 15 mg/L
Additional information
A semi-static test design according to OECD 202 was chosen in a GLP study to evaluate the acute toxicity of aluminium magnesium vanadium oxide to Daphnia magna at nominal concentrations from 10 to 100 mg/L (2013).
The substance has low water solubility and therefore the test solution was prepared by adding the appropriate test item to 1 liter of dilution water. After shaking vigorously for 24 hours the resulting solution was filtrated through 0.45 µm filters. Following this, the filtrates were used for the main test without dilution. The test solutions included the dilution water control and nominal concentrations of 10, 18, 32, 56 and 100 mg/L test item. The corresponding mean measured concentrations for Al were 0.18, 0.28, 0.40, 0.24, 0.54 mg/L (geom. mean) and the corresponding mean measured concentrations for V were 0.04, 0.06, 0.09, 0.09, 0.14 mg/L (geom. mean). Each treatment concentration was prepared separately and split into four aliquots for each replicate respectively. For analytical determinations of the test item Al and V concentrations in the test solutions were measured. The data show that the test item was present in the test solutions and that sufficient dissolution of the test item for the respective test concentrations was achieved. The 48 h-EL50 was determined as 15 mg/L (nominal, loading rate).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.