Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 692-448-4 | CAS number: 170621-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 - 19 Mar 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
- Version / remarks:
- 1984
- Qualifier:
- according to guideline
- Guideline:
- other: SEPA, The Guildelines for the Testing of Chemicals, 2004, 203 Fish Acute Toxicity Test
- GLP compliance:
- no
- Remarks:
- according to Chinese GLP (GB/T 22275.1-2008); comparable to OECD GLP C(97)186/FINAL
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: blank and 100 mg/L
- Sample storage conditions before analysis: samples were analysed directly - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test substance is a metal compound which contains Al, V and Mg. A loading rate of 100 mg/L of the test substance was prepared and stirred (via magnetic stirrer) in the dark at 700 rpm for 72 h. The test solution was then filtered by using a 0.45 μm nitrocellulose membrane - Test organisms (species):
- other: Gobiocypris rarus
- Details on test organisms:
- TEST ORGANISM
- Common name: Chinese rare minnow
- Source: Research Center for Eco-Environmental Science, Chinese Academy of Sciences (ID: GR-IHB-120919)
- Length at study initiation (length definition, mean, range and SD): mean: 1.7 cm; SD: 0.19 cm
- Weight at study initiation (mean and range, SD): mean: 0.13 g; SD: 0.02 g
- Feeding during test:
Food type: Brine Shrimp Aquarium Flake Food, O.S.I®
Amount: approximately 1% of body weight per day
Frequency: twice a day
ACCLIMATION
- Acclimation period: > 14 days
- Acclimation conditions (same as test or not): same as test
- Type and amount of food: Brine Shrimp Aquarium Flake Food, O.S.I®
- Feeding frequency: daily
- Health during acclimation (any mortality observed): No diseases were observed - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Hardness:
- 165 mg CaCO3/L
- Test temperature:
- 21.1 - 22.9 °C
- pH:
- 7.55 – 8.93
- Dissolved oxygen:
- 62.9% - 92.1% ASV
- Nominal and measured concentrations:
- Nominal concentration: control, 100 mg/L (loading rate)
Measured concentrations: see Any other information on results incl. tables - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 5 L glass tanks
- Aeration: continuously
- Renewal rate of test solution (frequency/flow rate): 48 h
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
- Biomass loading rate: 0.16 g fish/litre
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water dechlorinated by activated carbon and sterilized by UV lamp
- Intervals of water quality measurement: pH, dissolved oxygen and temperature: at 2 days intervals
OTHER TEST CONDITIONS
- Photoperiod: Light : Dark = 12 : 12 hours
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Mortalities and sublethal effects were observed and recorded daily - Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- NOELR
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- loading rate
- Basis for effect:
- mortality
- Key result
- Duration:
- 14 d
- Dose descriptor:
- NOELR
- Effect conc.:
- < 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- loading rate
- Basis for effect:
- growth rate
- Details on results:
- - Observed effects at each concentration for each observation time: No mortality occurred during the study, but the treatment had a significant effect on the specific growth rate of the fish (see Any other information on results incl. tables).
- Reported statistics and error estimates:
- The data analysis was performed with software TOXCALC (v5.0.26).
Reference
Measured concentrations of Al in the test solutions
Group |
0d |
2d - aged |
2d - new |
4d - aged |
4d - new |
6d - aged |
6d - new |
Mean (mg/L) |
||
Control [mg/L] |
1 |
0.0148 |
0.00418 |
0.00575 |
0.0135 |
0.0124 |
0.00829 |
0.0150 |
- |
- |
2 |
0.0141 |
0.00487 |
0.00591 |
0.0122 |
0.0109 |
0.00639 |
0.0151 |
- |
||
3 |
0.0147 |
0.00537 |
0.00613 |
0.0109 |
0.00983 |
0.00565 |
0.0153 |
- |
||
100 mg/L loading rate |
1 |
4.40 |
1.63 |
1.70 |
1.69 |
1.24 |
1.03 |
1.70 |
- |
- |
2 |
4.44 |
1.56 |
1.76 |
1.98 |
1.19 |
1.09 |
1.88 |
- |
||
3 |
4.44 |
1.56 |
1.74 |
1.89 |
1.28 |
0.984 |
1.82 |
- |
||
Group |
8d - aged |
8d - new |
10d - aged |
10d - new |
12d - aged |
12d - new |
14d - aged |
Mean (mg/L) |
||
Control group [mg/L] |
1 |
0.0150 |
0.00998 |
0.00969 |
0.0140 |
0.0126 |
0.0131 |
0.0128 |
- |
- |
2 |
0.0129 |
0.0136 |
0.00961 |
0.0133 |
0.0130 |
0.0133 |
0.0200 |
- |
||
3 |
0.0124 |
0.0133 |
0.00904 |
0.0127 |
0.0120 |
0.0133 |
0.0170 |
- |
||
100 mg/L loading rate
|
1 |
1.40 |
1.67 |
1.61 |
1.78 |
1.56 |
1.57 |
1.47 |
1.71 |
1.74 |
2 |
1.37 |
1.66 |
1.62 |
1.85 |
1.55 |
1.54 |
1.48 |
1.75 |
||
3 |
1.54 |
1.67 |
1.71 |
1.80 |
1.54 |
1.56 |
1.48 |
1.75 |
“-”, not available.
Measured concentrations of V in the test solutions
Group |
0d |
2d - aged |
2d - new |
4d - aged |
4d - new |
6d - aged |
6d - new |
Mean (mg/L) |
||
Control group [mg/L] |
1 |
0.000199 |
0.000587 |
0.000622 |
0.000380 |
0.000315 |
0.000288 |
0.000501 |
- |
- |
2 |
0.000174 |
0.000552 |
0.000623 |
0.000439 |
0.000308 |
0.000467 |
0.000474 |
- |
||
3 |
0.000178 |
0.000643 |
0.000663 |
0.000267 |
0.000321 |
0.000413 |
0.000476 |
- |
||
100 mg/L loading rate
|
1 |
1.40 |
0.564 |
0.584 |
0.584 |
0.480 |
0.468 |
0.568 |
- |
- |
2 |
1.42 |
0.584 |
0.584 |
0.584 |
0.480 |
0.488 |
0.568 |
- |
||
3 |
1.44 |
0.584 |
0.584 |
0.584 |
0.480 |
0.472 |
0.568 |
- |
||
Group |
8d - aged |
8d - new |
10d - aged |
10d - new |
12d - aged |
12d - new |
14d - aged |
Mean (mg/L) |
||
Control group [mg/L] |
1 |
0.000507 |
0.000448 |
0.000352 |
0.000383 |
0.000414 |
0.000283 |
0.000240 |
- |
- |
2 |
0.000388 |
0.000908 |
0.000234 |
0.000315 |
0.000387 |
0.000332 |
0.000331 |
- |
||
3 |
0.000526 |
0.000414 |
0.000355 |
0.000368 |
0.000342 |
0.000364 |
0.000472 |
- |
||
100 mg/L loading rate]
|
1 |
0.540 |
0.524 |
0.516 |
0.508 |
0.488 |
0.500 |
0.504 |
0.578 |
0.588 |
2 |
0.540 |
0.520 |
0.512 |
0.524 |
0.496 |
0.500 |
0.500 |
0.601 |
||
3 |
0.544 |
0.528 |
0.512 |
0.520 |
0.488 |
0.500 |
0.508 |
0.585
|
“-”, not available.
Measured concentrations of Mg in the test solutions
Group |
0d |
2d - aged |
2d - new |
4d - aged |
4d - new |
6d - aged |
6d - new |
Mean (mg/L) |
||
Control group [mg/L] |
1 |
8.49 |
7.05 |
7.73 |
8.26 |
7.24 |
8.36 |
7.73 |
- |
- |
2 |
8.75 |
8.38 |
7.78 |
7.89 |
7.64 |
8.18 |
7.69 |
- |
||
3 |
8.55 |
8.76 |
7.58 |
7.95 |
7.53 |
8.24 |
7.66 |
- |
||
100 mg/L loading rate |
1 |
15.8 |
14.9 |
15.4 |
16.4 |
14.2 |
16.0 |
15.9 |
- |
- |
2 |
15.7 |
14.6 |
16.6 |
16 |
14.4 |
16.0 |
16.1 |
- |
||
3 |
15.9 |
16.3 |
16.1 |
16.7 |
14.3 |
15.7 |
16.1 |
- |
||
Group |
8d - aged |
8d - new |
10d - aged |
10d - new |
12d - aged |
12d - new |
14d - aged |
Mean (mg/L) |
||
Control group [mg/L] |
1 |
7.10 |
7.08 |
7.79 |
7.36 |
7.59 |
7.19 |
7.47 |
- |
- |
2 |
6.92 |
7.08 |
8.21 |
7.25 |
7.45 |
7.11 |
7.34 |
- |
||
3 |
7.10 |
7.06 |
8.11 |
7.28 |
7.75 |
7.33 |
7.30 |
- |
||
100 mg/L loading rate |
1 |
14.8 |
14.7 |
14.9 |
15.0 |
15.1 |
15.2 |
15.3 |
15.3 |
15.3 |
2 |
14.8 |
14.7 |
14.4 |
14.9 |
14.9 |
14.9 |
15.0 |
15.3 |
||
3 |
14.6 |
14.6 |
14.9 |
15.0 |
14.9 |
15.0 |
15.2 |
15.4 |
“-”, not available.
The body weight and tank-average specific growth rate of test fish in the control group after 0 d and 14 d
Blank control Replicates |
Body weight (g) after 0d |
Body weight (g) after 14d |
Tank-average specific growth rate (%) |
||||||||||
1 |
2 |
3 |
4 |
5 |
Mean |
1 |
2 |
3 |
4 |
5 |
Mean |
||
1 |
0.1454 |
0.1275 |
0.1084 |
0.0981 |
0.1544 |
0.1267 |
0.1480 |
0.1562 |
0.1296 |
0.1477 |
0.1446 |
0.1452 |
0.9733 |
2 |
0.1359 |
0.1204 |
0.1515 |
0.1461 |
0.1505 |
0.1409 |
0.1452 |
0.1522 |
0.1487 |
0.1403 |
0.1494 |
0.1472 |
0.3114 |
3 |
0.1181 |
0.0999 |
0.1343 |
0.1053 |
0.1553 |
0.1226 |
0.1214 |
0.1914 |
0.1416 |
0.1586 |
0.0744 |
0.1375 |
0.8201 |
The body weight and tank-average specific growth rate of test fish in treatment groups after 0 d and 14 d
Treatment group |
Body weight (g) after 0d |
Body weight (g) after 14d |
Tank-average specific growth rate (%) |
|||||||||||
1 |
2 |
3 |
4 |
5 |
Mean |
1 |
2 |
3 |
4 |
5 |
Mean |
|||
100.0 |
1 |
0.1553 |
0.1558 |
0.1189 |
0.1164 |
0.1049 |
0.1303 |
0.0922 |
0.0792 |
0.0997 |
0.1103 |
0.1116 |
0.0986 |
-1.5774 |
2 |
0.1201 |
0.1068 |
0.0946 |
0.1336 |
0.1098 |
0.1130 |
0.1074 |
0.1187 |
0.1175 |
0.0696 |
0.0778 |
0.0982 |
-1.0018 |
|
3 |
0.1437 |
0.1040 |
0.1448 |
0.1171 |
0.1439 |
0.1307 |
0.1015 |
0.0873 |
0.0589 |
0.1038 |
0.0986 |
0.0900 |
-1.5875 |
Description of key information
NOELR(14d, growth rate) < 100 mg/L (nominal, loading rate) (OECD 204, Gobiocypris rarus). Measured concentration of Al, V, and Mg were 1.74 mg/L, 0.588 mg/L, and 15.3 mg/L
Key value for chemical safety assessment
Additional information
One study is available on the long-term toxicity of Aluminium magnesium vanadium oxide to fish. This key study was conducted as a semi-static limit test according to OECD Guideline 204 and Chinese GLP (2013). The test organism Gobiocypris rarus was exposed to a filtered test item solution of nominal 100 mg/L (loading rate) for 14 days. No mortality occurred during the study, but a significant difference in specific growth rate was observed between the control and the treatment group. The average recoveries of Al spiked 0.0200 mg/L and 0.160 mg/L samples were 117% and 103% with RSDs of 7.32% and 2.35%, respectively. The average recoveries of V spiked 0.0200 mg/L and 0.160 mg/L sample were 101% with RSDs of 1.24% and 1.13%, respectively. The average recoveries of Mg spiked 15 mg/L and 30 mg/L sample were 84.9% and 83.6% with RSDs of 1.04% and 0.77%, respectively. The NOELR based on mortality was determined to be 100 mg/L. For growth inhibition, the NOELR is below 100 mg/L. This corresponds to geometrich mean measured concentrations of Al, V and Mg of 1.74, 0.588, and 15.3 mg/L, respectively
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.