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1-(C12-C18 even numbered, C18 unsaturated)alkyl-1,4,5,6-tetrahydropyrimidin-2-aminium acetate and{[3-((C12-C18 even numbered, C18 unsaturated)alkylamino)propyl]amino}(imino)methanaminium acetate and[(3-{[ammonio(imino)methyl]amino}propyl)(C12-C18 even numbered, C18 unsaturated)alkylamino](imino)methanaminium diacetate
EC number: 939-650-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- At this time a In-vivo study was performed and therefore covers this endpoint.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD Guideline 405.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- C12-C16 (even numbered) alkyl-1,4,5,6-tetrahydropyrimidin-2-aminium acetate and {[3-(C12-C16 (even numbered)alkylamino)propyl]amino}(imino)methanaminium acetate and [(3-{[ammonio(imino)methyl]amino}propyl)-C12-C16 (even numbered)alkylamino](imino)methanaminium diacetate
- EC Number:
- 939-650-3
- Cas Number:
- 2770917-88-7
- IUPAC Name:
- C12-C16 (even numbered) alkyl-1,4,5,6-tetrahydropyrimidin-2-aminium acetate and {[3-(C12-C16 (even numbered)alkylamino)propyl]amino}(imino)methanaminium acetate and [(3-{[ammonio(imino)methyl]amino}propyl)-C12-C16 (even numbered)alkylamino](imino)methanaminium diacetate
- Test material form:
- other: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS- Source: Hoechst AG, conventional breeding- Age at study initiation: 3 - 5 month- Weight at study initiation: 3.5 - 3.8 kg- Housing: individual in stainless stell cages- Diet (e.g. ad libitum): ad libitum- Water (e.g. ad libitum): ad libitum- Acclimation period: at least 5 daysENVIRONMENTAL CONDITIONS- Temperature (°C): 20 +/-3°C- Humidity (%): 50 +/- 20 %- Air changes (per hr): 15- Photoperiod (hrs dark / hrs light): 12 hour interval
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 mL of the undiluted test item
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours (due to severe eye irritation reactions study was terminated after this reading)
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- 24 hours in advance to the study, the later tested eye of each rabbit was treated with fluoresceine Na-salt (0.01%) in order to check the cornea concerning defects. Only animals without diagnostic findings regarding the cornea were choosen for further testings.For the study 0.1 mL of the test item (concentration is 78 %; composition reported in confidential details on test material) was applied to the conjunctival sac of the left eye of each testing animal. The non treated eye served as control eye.Damages on the cornea, the iris and on the conjunctiva were numerical evaluated. All other changes were also recorded.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- all animals
- Basis:
- mean
- Remarks:
- over all
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: study terminated due to the severity of findings
- Irritation parameter:
- iris score
- Remarks:
- all animals
- Basis:
- mean
- Remarks:
- overall
- Time point:
- other: 24 hours
- Remarks on result:
- other: not assessable due to severe opacity of cornea
- Irritation parameter:
- conjunctivae score
- Remarks:
- all animals
- Basis:
- mean
- Remarks:
- overall
- Time point:
- other: 24 hours
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- other: study terminated due to severity of findings
- Irritation parameter:
- chemosis score
- Remarks:
- all animals
- Basis:
- mean
- Remarks:
- over all
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: study terminated due to severity of findings
- Irritant / corrosive response data:
- At the 24 hour reading severe eye irritation in form of opaque cornea, non assessable iris and severe chemosis including white discoloration of conjunctivae occurred. Based hereupon the study was terminated and the animals humanly killed.
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the study results, the test material is considered to be severly irritating to rabbit eyes.
- Executive summary:
In an OECD TG 405 study, 0.1 ml of the test material was applied to the eye of 3 New Zealand White rabbit. From 1 hour onwards, the conjunctiva showed red beefy discoloration and pronounced chemosis. The cornea exhibited opalescent areas or was opaque with no details of the iris visible. Because these lesions had progressed at the 24 hour reading, the study was terminated and the animals humanly killed for animal welfare reasons. Accordingly, the test item has to be considered as severely irritating to eyes.
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