1-(C12-C18 even numbered, C18 unsaturated)alkyl-1,4,5,6-tetrahydropyrimidin-2-aminium acetate and{[3-((C12-C18 even numbered, C18 unsaturated)alkylamino)propyl]amino}(imino)methanaminium acetate and[(3-{[ammonio(imino)methyl]amino}propyl)(C12-C18 even numbered, C18 unsaturated)alkylamino](imino)methanaminium diacetate

GHS

General Information

Name:

Reaction mass of C12-C16 (even numbered) alkyl-1,4,5,6-tetrahydropyrimidin-2-aminium acetate and {[3-(C12-C16 (even numbered) alkylamino) propyl]amino} (imino) methanaminium acetate and [(3-{[ammonio (imino) methyl]amino}propyl)-C12-C16 (even numbered) al

Implementation:

EU

Type of classification:

self-classification

Remarks:

Related composition:

Reaction mass of C12-C16 (even numbered) alkyl-1,4,5,6-tetrahydropyrimidin-2-aminium acetate and {[3-(C12-C16 (even numbered) alkylamino) propyl]amino} (imino) methanaminium acetate and [(3-{[ammonio (imino) methyl]amino}propyl)-C12-C16 (even numbered) alkylamino] (imino) methanaminium diacetate

Remarks: STOT RE 2 revised and no longer applicable.

Justification: Based on ECHA guidance on the application of the CLP criteria (version 3.0), substances are classified as specific target organ toxicants following repeated exposure by the use of expert judgement on the basis of the weight of all evidence available, including the use of recommended guidance values. In this respect, the evidence from studies with repeated dose toxicity studies indicate that the submission substance has the potential to be harmful to human health following repeated exposure. Looking closely at the effects occurred after repeated exposure all findings indicate an unspecific effect resulting from the local irritation of the gastrointestinal tract including the esophagus. This finding is supported by the corrosive property of the test substance. Due to the corrosivity of the test substance a reduced food intake resulting in a reduce body weight gain and inflammatory changes in hematology is observed as secondary effect. Local effects in the stomach were also observed in the new performed OECD 414 study which further supports the mainly irritating property of the test substance. Taking into account all these information a classification with STOR-RE 2 is not applicable since the local irritation/corrosion effect is already covered by the Skin Corrosion 1C classification.

Related composition

Related composition:

Legal Composition of the UVCB substance EC 939-650-3/ / CAS 2770917-88-7

Classification

Physical hazards

Explosives

Reason for no classification:

data conclusive but not sufficient for classification

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Reason for no classification:

data conclusive but not sufficient for classification

Flammable solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-reactive substances and mixtures

Reason for no classification:

data lacking

Pyrophoric liquids

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-heating substances and mixtures

Reason for no classification:

data lacking

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising liquids

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising solids

Reason for no classification:

data conclusive but not sufficient for classification

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data lacking

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Hazard category:

Acute Tox. 4

Hazard statement:

H302: Harmful if swallowed.

Acute toxicity - dermal

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - inhalation

Reason for no classification:

data conclusive but not sufficient for classification

Skin corrosion / irritation

Hazard category:

Skin Corr. 1C

Hazard statement:

H314: Causes severe skin burns and eye damage.

Serious eye damage / eye irritation

Reason for no classification:

data conclusive but not sufficient for classification

Respiratory sensitisation

Reason for no classification:

data conclusive but not sufficient for classification

Skin sensitisation

Reason for no classification:

data conclusive but not sufficient for classification

Aspiration hazard

Reason for no classification:

data lacking

Reproductive toxicity

Reason for no classification:

data lacking

Effects on or via lactation

Reason for no classification:

data lacking

Germ cell mutagenicity

Reason for no classification:

data conclusive but not sufficient for classification

Carcinogenicity

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - single (STOT-SE)

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - repeated (STOT-RE)

Reason for no classification:

data conclusive but not sufficient for classification

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Hazard category:

Aquatic Acute 1

Hazard statement:

H400: Very toxic to aquatic life.

Hazardous to the aquatic environment (long-term)

Hazard category:

Aquatic Chronic 1

Hazard statement:

H410: Very toxic to aquatic life with long lasting effects.

M-Factor acute:

10

M-Factor chronic:

1

Hazardous to the ozone layer

Reason for no classification:

data lacking

Labelling

Signal word:

Danger

Hazard pictogram

GHS05: corrosion

GHS07: exclamation mark

GHS09: environment

Hazard statements

H302: Harmful if swallowed.

H314: Causes severe skin burns and eye damage.

H410: Very toxic to aquatic life with long lasting effects.

Precautionary statements

P260: Do not breathe dust/fume/gas/mist/vapours/spray.

P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P301+P330+P331: IF SWALLOWED: rinse mouth. Do NOT induce vomiting.

P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P310: Immediately call a POISON CENTER/doctor/…

P273: Avoid release to the environment.

P391: Collect spillage.

P501: Dispose of contents/container to ...

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