Iodine pentafluoride

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Available ecotoxicity data on (hydrogen) fluoride up to 1998 was reviewed and summarised by the European Chemicals Bureau (ECB). Although detail on design and methodology is very limited in this report, endpoints and conclusions are considered suitably reliable for environmental risk assessment as the substance was assessed as part of the EU-RAR and in accordance with Council Regulation (EEC) 793/93 on the evaluation and control of risks of existing substances.

Data source

Reference

Reference Type:

publication

Title:

European Union Risk Assessment Report - Hydrogen Fluoride

Author:

Institute for Health and Consumer Protection, European Chemicals Bureau.

Year:

2001

Bibliographic source:

European Chemicals Bureau Existing Substances, 1st priority list, no. 8

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The EU-RAR summarises a number of long-term studies. Details on design and methodology are however not provided.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium fluoride

EC Number:

231-667-8

EC Name:

Sodium fluoride

Cas Number:

7681-49-4

IUPAC Name:

sodium fluoride

Test material form:

not specified

Details on test material:

In the EU-RAR it is stated that all reported tests with aquatic organisms were performed with NaF and that results were corrected for the fluoride ion.

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

21 d

Test conditions

Hardness:

250 mg CaCO3/L

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

3.7 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Effect concentrations 2

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

14.1 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

reproduction

Details on results:

In both long-term tests with daphnids the NOEC is based on effects on reproduction. The arithmetric mean of both tests gives a value of 8.9 mg/L for the NOEC.

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

The 21-day NOEC is 8.9 mg fluoride/L in Daphnia magna (arithmetic mean of both tests).

Executive summary:

The EU RAR summarises the findings of two long-term toxicity studies with Daphnia magna exposed to sodium fluoride. The two studies provide reproductive NOEC values of 3.7 and 14.1 mg fluoride/L. The arithmetic mean NOEC of both studies is 8.9 mg fluoride/L.