Registration Dossier
Registration Dossier
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EC number: 225-059-1 | CAS number: 4635-59-0
Endpoint summary
Administrative data
Description of key information
4-Chlorobutyryl chloride caused severe skin burns to the skin of rabbits under occlusive conditions. A single application of the ujndiluted substance to the rabbit eye caused cauterization.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
4-Chlorobutyryl chloride was applied to the skin of Vienna White rabbits for 1, 5 , 15 min and 20 hours (using 2 animals at all exposure durations) under occlusive conditions and animals were observed for 8 days in a study comparable to OECD guideline 404 (BASF AG, 1973). At 24 hours and 3 days, (severe) necrosis was reported after 5 min of exposure or longer (15 min and 20 hrs).
4 -Chlorobutyryl chloride was judged to be highly corrosive to the skin.
Eye irritation
4-Chlorobutyryl chloride was applied to conjunctival sac of the eyes of 2 Vienna White rabbits in a study comparable to OECD guideline 405 (BASF AG, 1973). Animals were observed after 1 and 24 hours and up to 8 days after the treatment. The application caused cauterization of the eyes. The substance was judged corrosive to the eyes.
Effects on skin irritation/corrosion: highly corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on the available data, 4-Chlorobutyryl chloride needs to be classified as corrosive to the skin and eyes according to Directive 67/548/EEC (C, R35) and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 Category 1A, H314).
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