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EC number: 431-060-1 | CAS number: 153719-38-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A Klimisch-1-rated 28-days feeding study was conducted with rats in 1997. The study also included a recovery period of one month. At an approximate test substance intake of 85 mg/kg bw/d certain adeverse effects on liver and kidney were being observed. After discussing the observed effects, it is concluded that no classification of CA 2343 as to its repeated dose toxicity effects is necessary.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 85 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
At 5000 ppm test substance in the food (i.e. substance intake ca. 400 mg/kg bw/d), and also in some animals receiving 1000 ppm (ca. 85 mg/kg bw/d), changes to plasma levels of proteins, glucose, bilirubin, cholesterol, and triglycerides were noted and increased activities of liver enzymes were indicative of hepatotoxic and hepatotropic effects. This was confirmed by the major histopathologic findings of hepatocellular hypertrophy and necrosis. At 1000 ppm, slight hepatotropic effects were noted in both sexes. Slight nephrotropic effects in males were typical for an alpha- 2 -microglobulin accumulation. In some males slight hypocellularity of the bone marrow was observed. Reversibility was incomplete for hepatotropic effects, but was generally more pronounced in males than in females.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver; urogenital: kidneys
Justification for classification or non-classification
A LOAEL of 85 mg/kg bw/day was being observed for both sexes, based on nominal concentrations. In the OECD-GHS classification system, the test substance basically could get classified as "Specific Target Organ Toxicity, category 2" (i.e. "harmful, R48/22" acc. to the DSD classification system) when during a 28 -d study on rats the result is 30 mg/kg bw/d > LOAEL > 300 mg/kg bw/d. However, the second condition for classification is that "significant organ damage" has to be observed. This is not considered to be the case here, since hypertrophy was the most severe effect reported, which is not assessed being a "significant organ damage". Furthermore these effects were was also partly reversible during the recovery period of one month, so full recovery deems to be possible if a longer recovery period would have been observed during the study. Overall, taking into account all of the arguments discussed above, no classification of test item CA 2343 is suggested as to its specific target organ toxicity.
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