Registration Dossier
Registration Dossier
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EC number: 601-672-3 | CAS number: 120118-14-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- 5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
- EC Number:
- 601-672-3
- Cas Number:
- 120118-14-1
- Molecular formula:
- C11H8ClN3
- IUPAC Name:
- 5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: SPF-bred guinea pigs of the strain Hsd Poc:DH
- Sex:
- male
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- polyethylene glycol
- Concentration / amount:
- intradermal induction: 5 % (= 20 mg CCIM/animal)
topical induction: 25 % (= 125 mg/animal)
challenge: 12 % (= 60 mg/animal)
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- polyethylene glycol
- Concentration / amount:
- intradermal induction: 5 % (= 20 mg CCIM/animal)
topical induction: 25 % (= 125 mg/animal)
challenge: 12 % (= 60 mg/animal)
- No. of animals per dose:
- 10 male animals for the test item group
5 male animals for the control
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 12 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: . Hours after challenge: 48.0. Group: test group. Dose level: 12 %. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 12 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: . Hours after challenge: 72.0. Group: test group. Dose level: 12 %. No with. + reactions: 0.0. Total no. in groups: 10.0.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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