Registration Dossier
Registration Dossier
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EC number: 601-672-3 | CAS number: 120118-14-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Non-human data:
Data on acute toxicity of chloro-cyano-p-tolyl-imidazole were available and several LD50 values for acute toxicity after oral application were reported:
In one oral acute toxicity study with Sprague-Dawley rats LD50 values of 324 and 443 mg/kg bw/day were reported for males and females, respectively.
In another oral acute toxicity studies with rats LD50 values between 300 and 500 mg/kg bw/day were reported. For this study the data submitter is data owner and the study was reported in more detail (see endpoint study record).
General clinical symptoms for acute toxicity in rodents are prone position, hunchback position, decrease in spontaneous motor activity, crawling, deep respiration, sedation, tremor, ptosis, salivation and soiled fur in the nasorostral region. These sign began to appear from 1 hour after administration and disappeared by day 1. At necropsy for the dead animals the gross findings were red-colored lung, red spots and edema in the lung, black spots in the glandular stomach, red-colored small intestine, edema in the small intestine, and soiled fur in the nasorostral regions. No macroscoplic abnormalities were noted in surviving animals at necropsy (day 14).
Human data:
No data available.
Justification for classification or non-classification
Oral:
Based on Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP), chloro-cyano-p-tolyl-imidazole was classified as harmful if swallowed (Xn, R22; cat 4, H302).
Inhalation:
Based on Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP), chloro-cyano-p-tolyl-imidazole was not classified for acute inhalative toxicity.
Dermal:
Based on Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP), chloro-cyano-p-tolyl-imidazole was not classified for acute dermal toxicity.
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