Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 950-299-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- End points of target substance di-, tri-, tetra- chlorotetradecane can be read across from source substance Alkanes, C14-17, chloro EC number: 287-477-0 | CAS number: 85535-85-9. This due to the following comparison:
1) di-, tri-, tetra- chlorotetradecane components make up the C14 content found in Alkanes, C14-17, chloro. It is therefore logical that di-, tri-, tetra- chlorotetradecane has been tested as a component of the larger group Alkanes, C14-17, chloro EC number: 287-477-0
2) The target and read-across molecules are both straight chain and therefore it is considered there are no major difference in steric hindrance between the substances (due to branched chain structures)
3) The functional groups are consistent between the target and read across substances, both are predominantly chlorinated alkanes
The degree of chlorination can affect the (eco)toxicology and physicochemical properties of the substance. The Substance Evaluation Conclusion Document for Medium-chain chlorinated paraffins /
alkanes, C14-17, chloro, EC No 287-477-0, CAS No 85535-85-9 conducted by evaluating members state United Kingdom (2019) https://echa.europa.eu/documents/10162/a72b228a-e417-5b53-b2b9-3b45c8e6eec5 includes direct comparisons of chlorinated alkanes with varying carbon chain lengths and chlorination for physical chemical tests and biodegradability screening tests. Examples include trend in Log Kow increasing with carbon chain length and vapour pressure decreasing with increased chlorination. A trend in biodegradation studies was also noted, increased chain length and chlorination severely disrupted the biodegradation processes.
To increase the accuracy of the read across, studies used from the Alkanes, C14-17, chloro REACH dossier will only include studies that used C14 components and similar levels of chlorination to di-, tri-, tetra- chlorotetradecane – 35 to 52 % chlorination. - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 800 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- The harmful threshold (24-hr; no further details given) was reported as 800 mg/l
- Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- no data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The harmful threshold (24 h) of a C14-17 chlorinated paraffin (41% chlorinated) to anaerobic bacteria from a domestic waste water treatment plant using the ETAD fermentation method was reported as 800 mg/l (considered the NOEC for this study).
- Executive summary:
No study has been reported for di-, tri-, tetra- chlorotetradecane, but data have been reported for the principal constituents of di-, tri-, tetra- chlorotetradecane that are found in the similar substance Alkanes, C14-17, chloro. However, as Alkanes, C14-17, chloro contains a broad range of chloro-alkanes, only reports using test material containing C14 chloro-alkanes and similar levels of chlorination (35 to 52 % chlorination) have been used for the purposes of read across.
The harmful threshold (24 h) of a C14-17 chlorinated paraffin (41% chlorinated) to anaerobic bacteria from a domestic waste water treatment plant using the ETAD fermentation method was reported as 800 mg/l (considered the NOEC for this study).
Using read across, it can be concluded the di-, tri-, tetra- chlorotetradecane would show similar conclusion.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- End points of target substance di-, tri-, tetra- chlorotetradecane can be read across from source substance Alkanes, C14-17, chloro EC number: 287-477-0 | CAS number: 85535-85-9. This due to the following comparison:
1) di-, tri-, tetra- chlorotetradecane components make up the C14 content found in Alkanes, C14-17, chloro. It is therefore logical that di-, tri-, tetra- chlorotetradecane has been tested as a component of the larger group Alkanes, C14-17, chloro EC number: 287-477-0
2) The target and read-across molecules are both straight chain and therefore it is considered there are no major difference in steric hindrance between the substances (due to branched chain structures)
3) The functional groups are consistent between the target and read across substances, both are predominantly chlorinated alkanes
The degree of chlorination can affect the (eco)toxicology and physicochemical properties of the substance. The Substance Evaluation Conclusion Document for Medium-chain chlorinated paraffins /
alkanes, C14-17, chloro, EC No 287-477-0, CAS No 85535-85-9 conducted by evaluating members state United Kingdom (2019) https://echa.europa.eu/documents/10162/a72b228a-e417-5b53-b2b9-3b45c8e6eec5 includes direct comparisons of chlorinated alkanes with varying carbon chain lengths and chlorination for physical chemical tests and biodegradability screening tests. Examples include trend in Log Kow increasing with carbon chain length and vapour pressure decreasing with increased chlorination. A trend in biodegradation studies was also noted, increased chain length and chlorination severely disrupted the biodegradation processes.
To increase the accuracy of the read across, studies used from the Alkanes, C14-17, chloro REACH dossier will only include studies that used C14 components and similar levels of chlorination to di-, tri-, tetra- chlorotetradecane – 35 to 52 % chlorination. - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 2 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- No inhibition of respiration seen at a concentration of up to 2000 mg/l
- Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- no data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The respiration of microorganisms in activated sludge over 3 h was unaffected by the presence of a C14-17 chlorinated paraffin (52% chlorinated) at concentrations up to 2000 mg/l (considered the NOEC for this study).
Using read across, it can be concluded the di-, tri-, tetra- chlorotetradecane would produce a similar result. - Executive summary:
No study has been reported for di-, tri-, tetra- chlorotetradecane, but data have been reported for the principal constituents of di-, tri-, tetra- chlorotetradecane that are found in the similar substance Alkanes, C14-17, chloro. However, as Alkanes, C14-17, chloro contains a broad range of chloro-alkanes, only reports using test material containing C14 chloro-alkanes and similar levels of chlorination (35 to 52 % chlorination) have been used for the purposes of read across.
In an OECD (209) guideline study, the effect of a C14-17 chlorinated paraffin (52% chlorinated) on the respiration of micro-organisms in activated sludge recovered from a municipal sewage plant was examined.
No inhibition of respiration was seen over a 3-h period when sludge was exposed to the test substance, emulsified in water with nonylphenol ethoxylate (0.5 g/l), at concentrations up to 2000 mg/l (considered the NOEC for this study).
Using read across, it can be concluded the di-, tri-, tetra- chlorotetradecane would produce a similar result.
Referenceopen allclose all
Description of key information
The harmful threshold (24 h) of a C14-17 chlorinated paraffin (41% chlorinated) to anaerobic bacteria from a domestic waste water treatment plant using the ETAD fermentation method was reported as 800 mg/L (considerd the 24h NOEC for this study). The respiration of microorganisms in activated sludge from a municipal sewage treatment plant over 3 h was unaffected by the presence of a C14-17 chlorinated paraffin (52% chlorinated) at concentrations of up to 2000 mg/L (considered the 3h NOEC for this study).
For a conservative approach, the lowest NOEC of 800 mg/L will be used.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 800 mg/L
Additional information
In an unpublished study (with only limited reporting in the final RAR), the toxicity of a C14-17 chlorinated paraffin (41% chlorinated) to anaerobic bacteria from a domestic waste water treatment plant has been examined using the ETAD fermentation tube method. The harmful threshold (24 hour; no further details given) was reported as 800 mg/l (considered the NOEC for this study) (Hoescht, 1976). The NOEC of 800 mg/L reported in this study will be used for the derivation of the PNEC.
In another unpublished study (with only limited reporting in expert reviews), the effect of a C14-17 chlorinated paraffin (52% chlorinated) on the respiration of micro-organisms in activated sludge recovered from a municipal sewage plant was examined in a study apparently based on OECD Guideline 209. No inhibition of respiration was seen over a 3 h period when sludge was exposed to the test substance, emulsified in water with nonylphenol ethoxylate (0.5 g/L), at concentrations up to 2000 mg/L (considered the NOEC for this study) (Hoescht, 1985 cited in BUA, 1992 and EU, 2005).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.