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EC number: 950-299-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- End points of target substance di-, tri-, tetra- chlorotetradecane can be read across from source substance Alkanes, C14-17, chloro EC number: 287-477-0 | CAS number: 85535-85-9. This due to the following comparison:
1) di-, tri-, tetra- chlorotetradecane components make up the C14 content found in Alkanes, C14-17, chloro. It is therefore logical that di-, tri-, tetra- chlorotetradecane has been tested as a component of the larger group Alkanes, C14-17, chloro EC number: 287-477-0
2) The target and read-across molecules are both straight chain and therefore it is considered there are no major difference in steric hindrance between the substances (due to branched chain structures)
3) The functional groups are consistent between the target and read across substances, both are predominantly chlorinated alkanes
The degree of chlorination can affect the (eco)toxicology and physicochemical properties of the substance. The Substance Evaluation Conclusion Document for Medium-chain chlorinated paraffins /
alkanes, C14-17, chloro, EC No 287-477-0, CAS No 85535-85-9 conducted by evaluating members state United Kingdom (2019) https://echa.europa.eu/documents/10162/a72b228a-e417-5b53-b2b9-3b45c8e6eec5 includes direct comparisons of chlorinated alkanes with varying carbon chain lengths and chlorination for physical chemical tests and biodegradability screening tests. Examples include trend in Log Kow increasing with carbon chain length and vapour pressure decreasing with increased chlorination. A trend in biodegradation studies was also noted, increased chain length and chlorination severely disrupted the biodegradation processes.
To increase the accuracy of the read across, studies used from the Alkanes, C14-17, chloro REACH dossier will only include studies that used C14 components and similar levels of chlorination to di-, tri-, tetra- chlorotetradecane – 35 to 52 % chlorination.
For the above reasons the required endpoint is sufficiently covered by the testing on the read across substance Alkanes, C14-17, chloro EC number: 287-477-0 and the hazard adequately assessed. It is therefore considered that further testing is not required. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Type:
- log Pow
- Partition coefficient:
- > 5.88 - < 6.82
- Temp.:
- 18.7 °C
- pH:
- ca. 6
- Remarks on result:
- other:
- Remarks:
- C14 50% Cl.
- Conclusions:
- The calculated weighted average log KOW (log KOW,Av) value for triplicate experimental set-ups was 6.58 with a standard deviation of 0.09. The experimental values are in agreement with the lower range of predicted KOW values by others. The log KOW values of C14 with different chlorine numbers varied between 5.98 and 6.96, and showed no trend with the chlorine number.
- Executive summary:
No study has been reported for di-, tri-, tetra- chlorotetradecane, but data have been reported for the principal constituents of di-, tri-, tetra- chlorotetradecane that are found in the similar substance Alkanes, C14-17, chloro. However, as Alkanes, C14-17, chloro contains a broad range of chloro-alkanes, only reports using test material containing C14 chloro-alkanes and similar levels of chlorination (35 to 52 % chlorination) have been used for the purposes of read across.
The calculated weighted average log KOW (log KOW,Av) value for triplicate experimental set-ups was 6.58 with a standard deviation of 0.09. The experimental values are in agreement with the lower range of predicted KOW values by others. The log KOW values of C14 with different chlorine numbers varied between 5.98 and 6.96, and showed no trend with the chlorine number. Refer to endpoint usmmary for log Pow of di-, tri-, tetra- chlorotetradecane.
Reference
Description of key information
Taking into account key and supporting studies, the geometric mean was calculated from the results using C14, 42% Cl = 6.95; C14, 57% Cl = 6.37; C16, 35% Cl = 4.7 -8.3; C14-17, 45% Cl = 5.52 -8.21; C14-17, 52% Cl = 5.47 -8.01.Average of each range middle = 6.6 log Pow
Average of each range middle = 6.6 log Pow
Using read across, it can be concluded di-, tri-, tetra- chlorotetradecane would have a log Pow of circa 6.6
Using read across, it can be concluded di-, tri-, tetra- chlorotetradecane would have a log Pow of circa 6.6
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.6
- at the temperature of:
- 20 °C
Additional information
The octanol-water partition coefficient of two C16 chlorinated paraffins was determined by high-performance liquid chromatography (HPLC) using 14C-labelled materials. The log Kow value for the 35% chlorinated paraffin was range 4.7-8.3 (Fisk et al. 1998).
Using reversed phase high performance thin layer chromatography, the octanol-water partition coefficients for components of two MCCPs have been determined. The derived partition coefficients, expressed as log Pow values, varied from 5.52-8.21 and between 5.47-8.01 for the 45% and 52% chlorinated C14-17 paraffins, respectively (Renberg et al. 1980).
Log Kow values of 6.95 for a C14 chlorinated paraffin (42% chlorinated), 6.37 for a C14 chlorinated paraffin (57% chlorinated), have been calculated using the CLOGP 3.4 computer program (BUA, 1992).
Overall, a log Kow value of 6.6 (geometric mean) will be used as a representative value.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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