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EC number: 405-520-5 | CAS number: 95235-30-6 D-8; DD-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-04-30 to 1986-07-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1175 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 4-(4-isopropoxyphenylsulfonyl)phenol
- EC Number:
- 405-520-5
- EC Name:
- 4-(4-isopropoxyphenylsulfonyl)phenol
- Cas Number:
- 95235-30-6
- Molecular formula:
- C15H16SO4
- IUPAC Name:
- 4-[4-(propan-2-yloxy)benzenesulfonyl]phenol
- Details on test material:
- - Name of test material (as cited in study report): D - 8
- Molecular formula: C15 H16 O4 S;
- Molecular weight: 292.4;
- Physical state: white powder;
- Analytical purity: > 99.5 %;
- Purity test date: not stated;
- Lot/batch No.: Not stated;
- Expiration date of the lot/batch: not stated;
- Stability under test conditions: stable at ambient temperature and conditions;
- Storage condition of test material: store in a cool dry place, protected from direct sunlight;
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Ltd.; Huntingdon; Cambridgeshire; England;
- Age at study initiation: four to six weeks;
- Weight at study initiation: 90 to 134 g;
- Fasting period before study: overnight prior to dosing;
- Housing: metal cages with wire-mesh plates;
- Diet: Labsure LAD 1 standard laboratory rodent diet ad libitum;
- Water: municipial tap water ad libitum;
- Acclimation period: 6 days;
ENVIRONMENTAL CONDITIONS
- Temperature: 21 to 23 °C;
- Humidity: mean 57 % R.H. daily;
- Air changes: 15 air changes per hour;
- Photoperiod: 12 hours dark/12 hours light per day;
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- D-8 was prepared at 50 % w/v in 1 % aqueous methylcellulose and administerd at a volume of 10.0 mL/kg.
The appropriate dose volume of the test substance was administered to each rat using a syringe and a plastic catheter. - Doses:
- 5.0 g/kg
- No. of animals per sex per dose:
- five males/five females
- Control animals:
- no
- Details on study design:
- Preliminary study:
A trial test was carried out by dosing two male and two female rats at 5.0 g/kg bw.
Main study:
A group of ten rats (five males and five females) was treated at 5.0 g/kg bw.
Results and discussion
- Preliminary study:
- No mortalities were observed during the preliminary study.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality was observed neither during the preliminary study nor the main study.
- Clinical signs:
- other: Pilo-erection, abnormal body carriage (hunched posture), abnormal gait (waddling), lethargy, pallor of extremities, increased salivation and diarrhoea were observed in all rats shortly after dosing. There were no other clinical signs and recovery, as judg
- Gross pathology:
- Terminal autopsy findings wrere normal.
- Other findings:
- No other findings
Any other information on results incl. tables
The acute lethal oral dose to rats of D-8 was found to be greater than 5.0 g/kg bw.
No mortalities were found during the observation period. No significant signs of toxic effects could be detected during necropsy.
Table: Results of toxicity testing of D-8
Study |
Dose (g/kg) |
Mortality ratio (no. of deaths/no. dosed) |
||
|
|
males |
females |
combined |
Preliminary |
5.0 |
0/2 |
0/2 |
0/4 |
Main |
5.0 |
0/5 |
0/5 |
0/10 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- D-8 was tested for acute oral toxicity in rats according to EU Test Guideline B.1. The acute lethal oral dose to rats of D-8 was found to be greater than 5000 mg/kg bw.
- Executive summary:
D-8 was tested for acute oral toxicity in rats. The substance was administered by gavage to male and female rats in a single dose of 5.0 g/kg bw. No mortalities occured during the observation period. No clinical signs of toxicity could be observed during necropsy after termination of the the study. It was concluded that the acute lethal oral dose for D-8 in rats was greater 5000 mg/kg bw.
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