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EC number: 602-927-1 | CAS number: 123312-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Other distribution data
Administrative data
- Endpoint:
- other distribution data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 02 Sep 1993 to 28 Sep 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Richtlinie fur die amtliche Prufung von Pflanzenschutzmitteln, Teil IV, 4-2: 'Versickerungsverhalten von Pflanzenschutzmitteln". Biologische Bundesanstalt für Land- und Forstwirtschaft Bundesrepublik Deutschland
- Version / remarks:
- December 1986
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Dutch Registration Guideline, Section G.1.2.B: Leaching through soil columns. Ministry of Agriculture and Fisheries, Ministry of Public Health and Environmental Hygiene, Ministry of Social Affairs
- Version / remarks:
- January 1987
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- soil leaching
- Media:
- water - soil
Test material
- Reference substance name:
- 6-methyl-4-[(E)-[(pyridin-3-yl)methylidene]amino]-2,3,4,5-tetrahydro-1,2,4-triazin-3-one
- EC Number:
- 602-927-1
- Cas Number:
- 123312-89-0
- Molecular formula:
- C10H11N5O
- IUPAC Name:
- 6-methyl-4-[(E)-[(pyridin-3-yl)methylidene]amino]-2,3,4,5-tetrahydro-1,2,4-triazin-3-one
Constituent 1
Results and discussion
Any other information on results incl. tables
In Collombey and Les Evouettes soils treated with the triazine labelled test substance, after 5 days of ageing, besides non-extractable radioactivity (19.9 and 18.8% of the dose) unchanged test substance (37.3 and 46.8 %), M1 (30.5 and 34.9 %), M12, and M4, (5.3 % of the dose applied) were found. Furthermore, a slight mineralisation of the triazine ring moiety of 0.9 and 0.5% CO2 was observed in Collombey and Les Evouettes soil, respectively. Total recoveries after ageing were 101.0 and 98.0% of the radioactivity applied for Les Evouettes and Collombey soil, respectively. Leaching of aged residues showed that 98.2 and 99.3 % of the radioactivity applied onto the soil columns were retained by the loamy sand and silt loam soil columns, respectively. Leachates of Collombey and Les Evouettes soil columns contained only a total of 0.1% of the activity applied for both soils. The latter figures corresponded to a residue level in the percolate of the corresponding soils of 0.0003 and 0.0002 μg/L. Total recoveries were determined to be 98.2 and 99.3%, for Collombey and Les Evouettes soil, respectively. However, analysis of the various soil layers showed that 41.3 and 62.8% the radioactivity totally applied onto the soil columns remained in the top layer (0-2 cm) of the columns, for Collombey loamy sand and Les Evouettes silt loam, respectively. In Collombey loamy sand, 24.3, 19.7, 6.9 and 3.6% of the radioactivity applied were determined in soil layers 2-4, 4-6, 6-8 and 8-10 cm, respectively. In Les Evouettes silt loam, 14.3, 15.7, 3.9 and 1.0% of the radioactivity applied were determined in soil layers 2-4, 4-6, 6-8 and 8-10 cm, respectively. In deeper layers of both soil columns only minor amounts of radioactivity (< 1% of the dose applied) could be detected. The extractable portions of radioactivity from the dissected soil layers of Collombey loamy sand were 26.4, 20.8, 17 .6, 6.0 and 3.1% of the radioactivity applied in layer 0-2, 2-4, 4-6, 6-8 and 8-10 cm, respectively. In Les Evouettes silt loam the extractable radioactivity in the dissected layers accounted for 51.4, 13.5, 14.9, 3.6 and 0.8% of the radioactivity applied in layer 0 2, 2-4, 4-6, 6-8 and 8-10 cm, respectively. The non-extractable fraction was at highest in the top soil layer (0-2 cm), accounting for 14.9 and 11.4% in Collombey and Les Evouettes soil, respectively. In the adjacent layers the amount of bound residue in both soil columns dropped down to ~ 0.2% of the amount applied from 14 - 16 cm on. The pattern of metabolites found in extractables of the various soil layers showed besides unchanged test substance, M1 and several other minor metabolites. Higher amounts of unchanged test substance remained only in the top layer (0-2 cm), i.e. 14.5 and 23.4% of the dose applied in Collombey and Les Evouettes soil, respectively. The most significant radioactive fraction besides the parent molecule in extracts was metabolite M1. In Collombey soil metabolite M1 was detected up to a leaching distance of 12 cm (0.3% of the dose applied), while the highest concentration of this fraction was observed in the 4-6 cm layer (11.6% of the radioactivity applied). In Les Evouettes soil metabolite M1 could be detected up to a leaching distance of 6 cm. The highest amount of M1 in this soil remained in the top layer, accounting for 18.2% of the dose applied. Based on the migration pattern into the soil profile the test substance and metabolites M5, M12 and M4 were found to be little mobile (mobility class: 2) and degradate M1 showed a low mobility (mobility class: 3). Therefore, neither the parent compound nor its soil metabolites represent a potential hazard for ground water contamination.
Applicant's summary and conclusion
- Conclusions:
- The test substance and metabolites M5, M12 and M4 were found to be little mobile (mobility class: 2) and degradate M1 showed a low mobility (mobility class: 3). Therefore, neither the parent compound nor its soil metabolites represent a potential hazard for ground water contamination.
- Executive summary:
The present experiments were designed to obtain information on the leaching behaviour of the 14C-triazine ring labelled test substance and its soil metabolites. The study was conducted in accordance with BBA part IV, 4-2 and was in compliance with GLP criteria. For this purpose, a loamy sand (Collombey) and a silt loam (Les Evouettes) were treated separately with a dose rate corresponding to 300 g a.i./ha. The treated soil samples were aged for 5 days(> one half-life) in a metabolism apparatus and then an aliquot was applied as 2-cm layer onto the top of untreated soil columns filled up to 28 cm with the same soil types. Artificial rainfall of 200 mm was applied over a period of two days, and the eluates were collected. After percolation the soil columns were dissected into 15 layers of 2 cm each and the layers submitted to extraction and analysis. Amounts and nature of radioactivity in the eluates and in soil layers after percolation were determined.
In Collombey and Les Evouettes soils treated with the triazine labelled test substance, after 5 days of ageing, besides non-extractable radioactivity (19.9 and 18.8% of the dose) unchanged test substance (37.3 and 46.8 %), M1 (30.5 and 34.9 %), M12, and M4, (5.3 % of the dose applied) were found. Furthermore, a slight mineralisation of the triazine ring moiety of 0.9 and 0.5% CO2 was observed in Collombey and Les Evouettes soil, respectively. Total recoveries after ageing were 101.0 and 98.0% of the radioactivity applied for Les Evouettes and Collombey soil, respectively. Leaching of aged residues showed that 98.2 and 99.3 % of the radioactivity applied onto the soil columns were retained by the loamy sand and silt loam soil columns, respectively. Leachates of Collombey and Les Evouettes soil columns contained only a total of 0.1% of the activity applied for both soils. Total recoveries were determined to be 98.2 and 99.3%, for Collombey and Les Evouettes soil, respectively. Analysis of the various soil layers showed that 41.3 and 62.8% the radioactivity totally applied onto the soil columns remained in the top layer (0-2 cm) of the columns, for Collombey loamy sand and Les Evouettes silt loam, respectively. In Collombey loamy sand, 24.3, 19.7, 6.9 and 3.6% of the radioactivity applied were determined in soil layers 2-4, 4-6, 6-8 and 8-10 cm, respectively. In Les Evouettes silt loam, 14.3, 15.7, 3.9 and 1.0% of the radioactivity applied were determined in soil layers 2-4, 4-6, 6-8 and 8-10 cm, respectively. In deeper layers of both soil columns only minor amounts of radioactivity (< 1% of the dose applied) could be detected. The extractable portions of radioactivity from the dissected soil layers of Collombey loamy sand were 26.4, 20.8, 17 .6, 6.0 and 3.1% of the radioactivity applied in layer 0-2, 2-4, 4-6, 6-8 and 8-10 cm, respectively. In Les Evouettes silt loam the extractable radioactivity in the dissected layers accounted for 51.4, 13.5, 14.9, 3.6 and 0.8% of the radioactivity applied in layer 0 2, 2-4, 4-6, 6-8 and 8-10 cm, respectively. The non-extractable fraction was at highest in the top soil layer (0-2 cm), accounting for 14.9 and 11.4% in Collombey and Les Evouettes soil, respectively. In the adjacent layers the amount of bound residue in both soil columns dropped down to ~ 0.2% of the amount applied from 14 - 16 cm on. The pattern of metabolites found in extractables of the various soil layers showed besides unchanged test substance, M1 and several other minor metabolites. Higher amounts of unchanged test substance remained only in the top layer (0-2 cm), i.e. 14.5 and 23.4% of the dose applied in Collombey and Les Evouettes soil, respectively. The most significant radioactive fraction besides the parent molecule in extracts was metabolite M1. In Collombey soil metabolite M1 was detected up to a leaching distance of 12 cm (0.3% of the dose applied), while the highest concentration of this fraction was observed in the 4-6 cm layer (11.6% of the radioactivity applied). In Les Evouettes soil metabolite M1 could be detected up to a leaching distance of 6 cm. The highest amount of M1 in this soil remained in the top layer, accounting for 18.2% of the dose applied. Based on the migration pattern into the soil profile the test substance and metabolites M5, M12 and M4 were found to be little mobile (mobility class: 2) and degradate M1 showed a low mobility (mobility class: 3). Therefore, neither the parent compound nor its soil metabolites represent a potential hazard for ground water contamination.
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