Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 602-927-1 | CAS number: 123312-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in soil
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in soil
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 26 Feb 2000 to 28 Aug 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-3 (Photodegradation Studies on Soil)
- GLP compliance:
- yes
- Radiolabelling:
- yes
- Remarks:
- [14C]-labelled at position 2 of pyridine ring
- DT50:
- 18.8 d
- Test condition:
- 25 °C; ~ 7.8E-03 W/cm
- DT50:
- 4.9 d
- Test condition:
- 25 °C; ~ 7.8E-03 W/cm; Dissolved phase
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The test substance degraded with a half life in the dissolved phase of 4.9 days and a rate constant of 0.14218 per day; the DT50 for the irradiated incubation was 18.8 days. Under dark conditions, the test substance degraded with a half life in the dissolved phase of 7.2 days and a rate constant of 0.09613 per day; the DT50 was 18.2 days.
- Executive summary:
A soil photolysis study was conducted with 14C-Pyridinyl-labelled test substance, in accordance with US EPA Environmental Fate Data Requirement 40 CFR Section 158 (Subdivision N, Series 161-3) and in compliance with GLP criteria. The photodegradation rate of the test substance was studied under artificial light at an average dose rate of 0.093 ppm which compares to the maximum recommended field use rate. The irradiated samples were irradiated with a xenon arc lamp for 12 hours per day at an average daily intensity of approximately 7.8E-03 W/cm . Samples were incubated up to 30 days as either irradiated or non-irradiated (dark control) samples. All samples were maintained at approximately 25°C. Harvest of samples was frequent enough to permit an accurate determination of the degradation half life and to monitor the formation and decline of degradates.
Degradation of the test substance on viable soil under photolytic conditions did not follow first-order kinetics. The test substance degraded with a half life in the dissolved phase of 4.9 days and a rate constant of 0.14218 per day. The DT50 for the irradiated incubation was approximately 18.8 days. 14C-Pyridinyl-labelled test substance on viable soil under non-irradiated conditions was not first order kinetics either. The test substance degraded with a half life in the dissolved phase of 7.2 days and a rate constant of 0.09613 per day. The DT50 for the nonirradiated incubation was observed at approximately 18.2 days.
Photolytic degradation of the test substance led to the formation of 11 degradates for the irradiated incubation as opposed to 14 degradates for the non-irradiated incubation. These degradates were qualitatively and quantitatively very similar. Each degradate accounted for less than an average of 9.51 % of total dose for the irradiated incubation and 8.76% of total dose for the non-irradiated incubation. Volatiles accounted for up to an average of 8.86% of the total dose for the irradiated incubations and 8.90% of the total dose for the non-irradiated incubations. Precipitation of the KOH fractions indicated CO2 was the major volatile component. Evidence from this study indicates that photolysis is a minor contributing factor to the degradation of the test substance on soil. The test substance and its degradates bind to the soil quickly and are not released under mild or mild/basic extractions. The major bound residues are only released with 0.5 M sodium hydroxide extraction. Humin/Humic/Fulvic characterization indicated the residues were bound to the fulvic soil fraction. Only three degradates, M3, M10, and M1, were co-chromatographed with reference standards. Only the test substance and two degradates, M1 and M3, were present in large enough quantity to be confirmed by mass spectral analysis.
Reference
Degradation of the test substance on viable soil under photolytic conditions did not follow first-order kinetics. The test substance degraded with a half life in the dissolved phase of 4.9 days and a rate constant of 0.14218 per day. The DT50 for the irradiated incubation was approximately 18.8 days. 14C-Pyridinyl-labelled test substance on viable soil under non-irradiated conditions was not first order kinetics either. The test substance degraded with a half life in the dissolved phase of 7.2 days and a rate constant of 0.09613 per day. The DT50 for the nonirradiated incubation was observed at approximately 18.2 days.
Photolytic degradation of the test substance led to the formation of 11 degradates for the irradiated incubation as opposed to 14 degradates for the non-irradiated incubation. These degradates were qualitatively and quantitatively very similar. Each degradate accounted for less than an average of 9.51 % of total dose for the irradiated incubation and 8.76% of total dose for the non-irradiated incubation. Volatiles accounted for up to an average of 8.86% of the total dose for the irradiated incubations and 8.90% of the total dose for the non-irradiated incubations. Precipitation of the KOH fractions indicated CO2 was the major volatile component. Evidence from this study indicates that photolysis is a minor contributing factor to the degradation of the test substance on soil. The test substance and its degradates bind to the soil quickly and are not released under mild or mild/basic extractions. The major bound residues are only released with 0.5 M sodium hydroxide extraction. Humin/Humic/Fulvic characterization indicated the residues were bound to the fulvic soil fraction. Only three degradates, M3, M10, and M1, were co-chromatographed with reference standards. Only the test substance and two degradates, M1 and M3, were present in large enough quantity to be confirmed by mass spectral analysis.
Description of key information
The DT50 for the irradiated incubation was 18.8 days; EPA Subdivision N, Series 161-3 - Sparrow 2000.
Information on this endpoint is not part of Annex VIII data requirements; all included studies are marked as supporting information and considered in the CSA.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.