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Diss Factsheets
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EC number: 452-810-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-01-08 to 2004-03-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to standard test guidelines (OECD 111, EC) and conform GLP requirements. The results of the study can be considered reliable without restriction.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: After incubation, aliquots of each test solution (10 µL) were analysed at the beginning, after 2.4 h and after 120 h.
- Sampling intervals/times for pH measurements: not reported
- Sampling intervals/times for sterility check: not reported
- Sample storage conditions before analysis: not reported - Buffers:
- - pH: 4, 7, 9
- Type of buffer:
* pH 4: component: biphthalate
* pH 7: component: phosphate
* pH 9: component: borate
- Buffer solutions were sterilized for 25 min in an autoclave prior to first use.
- Nitrogen was passed through the buffer solutions for 5 minutes except when freshly sterilized. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 50-mL glass Erlenmeyer flasks stoppered or sealed with inert material (e.g PTFE), fillvolume 50 mL
- Sterilisation method: glassware rinsed with sterile buffer, buffer solutions autoclaved for 25 minutes
- Lighting: not reported
- Measures to exclude oxygen: nitrogen passed through buffer solutions for 5 min to reduce the oxygen in the solution.
TEST MEDIUM
- Volume used/treatment: 50 mL
- Kind and purity of water: water from Milli-Q supply
- Preparation of test medium: an amount of T002251 was dissolved in 2 mL DMF as solubilizer with aid of sonication and filled up to 100 mL with buffer solution (pH 4, 7 or 9). The solution was filtrated (0.45 µm) and diluted in a 1:1 ratio with the respective buffer solution. 2 aliquots of this solution of ~50 mL each were transferred into 50 mL flasks in order to perform a duplicate test. - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 92.589 - <= 93.793 other: µg/mL
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 91.731 - <= 91.984 other: µg/mL
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 95.952 - <= 96.041 other: µg/mL
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- not specified
- Preliminary study:
- A preliminary study was performed at 50°C ± 1 °C at each of pH 4, 7 and 9 in duplicate. Results are as follows:
pH 4*
- 0 hours: initial concentration measured: 93.191 µg/mL
- 2.4 hours: concentration measured: 92.9645 µg/mL
- 5 days: concentration measured: 93.5475 µg/mL
pH 7*
- 0 hours: initial concentration measured: 91.8575 µg/mL
- 2.4 hours: concentration measured: 91.287 µg/mL
- 5 days: concentration measured: 92.451 µg/mL
pH 9*
- 0 hours: initial concentration measured: 95.9965 µg/mL
- 2.4 hours: concentration measured: 96.16 µg/mL
- 5 days: concentration measured: 97.482 µg/mL
* values reported are the mean of 2 concentrations measured. - Test performance:
- At pH 4.0, 7.0 and 9.0 the test item was found to be stable at 50°C. Therefore, no further testing was performed.
- Transformation products:
- not specified
- Details on hydrolysis and appearance of transformation product(s):
- no data
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: no data
- Anomalies or problems encountered (if yes): no data
MAJOR TRANSFORMATION PRODUCTS
- no data reported
MINOR TRANSFORMATION PRODUCTS
- no data reported
MINERALISATION (distinguish between dark and irradiated samples)
- no data reported
INDICATION OF UNSTABLE TRANSFORMATION PRODUCTS:
- no data reported
VOLATILIZATION (at end of study)
- no data reported
PATHWAYS OF HYDROLYSIS
- no data reported
UNIDENTIFIED RADIOACTIVITY (at end of study)
- no data reported - Validity criteria fulfilled:
- yes
- Conclusions:
- Hydrolysis was studied for T002251 following guideline OECD 111 during 5 days at pH 4, 7 and 9 and at 50°C. During the preliminary study, T002251 was found to be stable at pH 4.0, pH 7.0 and pH 9.0 (the degradation of T002251 was less than 10% after 5 days). It was concluded that the estimated half-life time at 25°C is longer than 1 year at pH 4.0, 7.0 and 9.0. The results of the test can be considered reliable without restriction.
Reference
Description of key information
One study (Tognucci, 2004) was performed according to OECD guideline 111 and regarded as a key study (Klimisch score of 1). A half-life time of > 1 year at 25 °C and pH 7 was determined for T002251.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.