Quaternary ammonium compounds, C12-14 (even numbered) alkyl(hydroxyethyl)dimethyl, C12 alkylbis(hydroxyethyl)methyl, chlorides and amines, C12-14 (even numbered) alkyldimethyl, chlorides

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From December 05, 2018 to December 06, 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 181

Version / remarks:

CIPAC MT 181: “Solubility in organic solvents”, CIPAC Handbook H, 1998

Deviations:

no

Principles of method if other than guideline:

The study was performed in order to determine the miscibility of test substance with solvent n-octanol according to CIPAC MT 181. The test substance was mixed with different amounts of n-octanol. From the total volume, which was required for complete dissolution of a certain mass of the test substance, examined visually after at least 30 minutes, the solubility in n-octanol was determined.

GLP compliance:

yes (incl. QA statement)

Key result

Medium:

n-octanol

Solubility:

ca. 33 - ca. 40 g/L

Temp.:

20 °C

Remarks on result:

other: equivalent to 13-16 g a.i./L

Test substance stable:

not determined

Results

Pre-Test n-octanol

Weight test substance [g]	0.999
Added Volume [mL]	0.5	1.0	2.0	3.0
Approx.Solubility[g/L]	> 200	100-200	50-100	33-50
Dissolution	no	no	nearly	Yes*

*No Tyndall effect was visible with the Laser pointer.

In n-octanol dissolution of 33 – 50 g/L of the test substance was observed.

 

Main-Test 

Determination	1			2
Weight test substance [g]	0.1007			0.1012
Added Volume[mL]	2.0	2.5	3.0	2.0	2.5	3.0
Approx. Solubility [g/L]	> 50	40-50	33-40	> 50	40-50	33-40
Dissolution	no	no	yes*	no	no	yes*

*No Tyndall effect was visible with the Laser pointer.

Discussion

The results of the pre-test (33 – 50 g/L) were confirmed in the main test (33 -40 g/L). The main test showed good repeatability. Solubility in n-octanol is 33 – 40 g/L. Solubility in n- octanol, calculated based on active matter content (content of UVCB component Quaternary ammonium compounds, C12-14alkyl(hydroxyethyl)dimethyl, chlorides in the test substance: 39.6%) is 13 – 16 g/L. No doubts have arisen concerning the accuracy of the results and the validity of the study.

Conclusions:

Under the study conditions, the n-octanol solubility of the test substance was determined to be 33 -40 g/L of solution at 20.0 ± 0.5°C (equivalent to 13 -16 g a.i./L).

Executive summary:

A study was conducted to determine the n-octanol solubility of the test substance, C12 -14 HEDMAC ( 39.6% active) using a measuring test tube method according to CIPAC MT 181, in compliance with GLP. Under the study conditions, the n-octanol solubility of the test substance was determined to be 33 -40 g/L of solution at 20.0 ± 0.5°C (equivalent to 13-16 g a.i./L) (Brinkmann, 2019).

Description of key information

The solubility in organic solvents of the test substance (39.6% active) was determined using the flask method, according to CIPAC MT 181 (Brinkmann, 2012).

Key value for chemical safety assessment

At the temperature of:

20 °C

Solubility in organic solvents at 20°C:

16 g/L

Additional information

(n-octanol solubility: 13 -16 g a.i./L)