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Registration Dossier
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EC number: 237-725-9 | CAS number: 13945-76-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov 03 - 09, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- column elution method
- Water solubility:
- < 1 µg/L
- Temp.:
- 20 °C
- pH:
- 6.3
- Remarks on result:
- other: below LOQ
Reference
After substraction of the blank value:
Flow rate [mL/h] |
Fraction No. |
Volume of combined fractions [mL] |
IS [µg/L] |
Solubility of test item [µg/L]* |
||
25.0 |
1 (1-2) |
20 |
96.5 |
2.03 |
||
|
2 (3-4) |
20 |
96.5 |
< 1 |
||
|
3 (5-6) |
20 |
96.5 |
< 1 |
||
|
4 (7-8) |
20 |
96.5 |
< 1 |
||
|
5 (9-10) |
20 |
96.5 |
< 1 |
||
|
6 (11-12) |
20 |
96.5 |
< 1 |
||
|
7 (13-14) |
20 |
96.5 |
< 1 |
||
|
8 (15-16) |
20 |
96.5 |
< 1 |
||
|
|
|
|
|
|
|
6.25 |
1 (1-2) |
20 |
96.5 |
8.27 |
||
|
2 (3-4) |
20 |
96.5 |
< 1 |
||
|
3 (5-6) |
20 |
96.5 |
< 1 |
||
|
4 (7-8) |
20 |
96.5 |
< 1 |
||
|
5 (9-10) |
20 |
96.5 |
< 1 |
||
|
6 (11-12) |
20 |
96.5 |
< 1 |
||
|
7 (13-14) |
20 |
96.5 |
< 1 |
||
|
8 (15-16) |
20 |
96.5 |
< 1 |
||
* the blank value is subtracted from the results, due to superposition
The water solubility at a flow rate of 25 mL/h yielded values from <1 µg/L and 2.03 µg/L and at a flow rate 12.5 mL <1 µg/L to 8.27 µg/L. In contradiction to the OECD Guideline 105 the concentrations differ by more than 30 %. This is, however, due to the low solubility of the test item. Therefore, a larger difference is also considered acceptable.
Calculation of water solubility was done by means of five successive fraction due to the signals of the first fractions of each run.
rate [mL/h] |
Fraction No. |
Test item |
Mean value [µg/L] |
25 |
3 (5 -6) |
<1 |
<1 |
4 (7 -8) |
≤1 |
||
5 (9-10) |
< 1 |
||
6 (11-12) |
< 1 |
||
7 (13-14) |
<1 |
||
12.5 |
3 (5 -6) |
<1 |
<1 |
| 4 (7-8) | <1 | ||
| 5 (9 -10) | <1 | ||
| 6 (11 -12) | <1 | ||
| 7 (13 -14) | <1 |
The WS was determined at 20 °C. The pH value of the collected aqueous fractions was 6.3.
Description of key information
< 1 µg/L at 20 °C and pH = 6.3, below LOQ (OECD 105)
Key value for chemical safety assessment
Additional information
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