Registration Dossier
Registration Dossier
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EC number: 205-450-3 | CAS number: 141-04-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- no
- Type of study:
- Draize test
- Justification for non-LLNA method:
- Draize test on humans
Test material
- Reference substance name:
- Diisobutyl adipate
- EC Number:
- 205-450-3
- EC Name:
- Diisobutyl adipate
- Cas Number:
- 141-04-8
- Molecular formula:
- C14H26O4
- IUPAC Name:
- diisobutyl adipate
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- other: Homo Sapiens Sapiens
- Strain:
- not specified
- Sex:
- male/female
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 12
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no sensitisation observed
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- rechallenge
- Hours after challenge:
- 12
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no sensitisation observed
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- not sensitizing, no skin response observed
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