Registration Dossier
Registration Dossier
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EC number: 205-450-3 | CAS number: 141-04-8
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Dibutyl adipate
- EC Number:
- 203-350-4
- EC Name:
- Dibutyl adipate
- Cas Number:
- 105-99-7
- Molecular formula:
- C14H26O4
- IUPAC Name:
- dibutyl adipate
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Stock solutions was prepared with DMSO:HC 40 = 9:1 (200 mg/l). Controls with and without this vehicle were taken for the test
Test organisms
- Test organisms (species):
- Oryzias latipes
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Nominal and measured concentrations:
- A group of 10 fishes were exposed to 5 nominal concentrations (1.0-10 mg/l)
- Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 3.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 5.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 4.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Key result
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 3.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- LC50 (24h) = 5.1 mg/l (95% confidence limits: 4.2-6.0 mg/l)
LC50 (48h) = 4.1 mg/l(95% confidence limits:3.2-5.2 mg/l)
LC50 (72h) = 3.7 mg/l (95% confidence limits: 2.9-4.8 mg/l)
LC50 (96h) = 3.7 mg/l (95% confidence limits: 2.9-4.8 mg/l)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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