Registration Dossier
Registration Dossier
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EC number: 220-168-0 | CAS number: 2650-18-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Extensive investigations, but insufficient documentation
- Remarks:
- The study is conducted on a read across test material. The complete read across justification is attached in section 13. The reliability of the original study is 4.
Data source
Reference
- Reference Type:
- publication
- Title:
- Über die Erzeugung von Sarkomen durch die besonders gereinigten Triphenylmnethanfarbstof!e Lichtgrün SF und Patentblau AE bei der wiederholten subkutanen Injektion an der Ratte
- Author:
- Gross, E.
- Year:
- 1 961
- Bibliographic source:
- Zeitschrift für Krebsforschung, Vol 64, pp 287-304
Materials and methods
- Principles of method if other than guideline:
- intraperitoneal injection with post-observation period
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Similar Substance 1
- IUPAC Name:
- Similar Substance 1
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- physiological saline
- Doses:
- 4600 mg/kg bw
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 4 600 mg/kg bw
- Other findings:
- Parenteral application of the substance resulted quickly in a whole-body blue colouration with the exception of the lungs. The blue colouration persisted for a few days. Clearance of the colour was observed via the bile and the urine.
Applicant's summary and conclusion
- Conclusions:
- The substance is of low acute toxicity after intraperitoneal injection in mice.
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