3-pyridyl dimethylcarbamate

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002-02-13 to 2002-02-21

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))

Deviations:

no

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3-pyridyl dimethylcarbamate

EC Number:

257-297-7

EC Name:

3-pyridyl dimethylcarbamate

Cas Number:

51581-32-9

Molecular formula:

C8H10N2O2

IUPAC Name:

pyridin-3-yl N,N-dimethylcarbamate

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

yes

Details on test solutions:

test materials was dissolved in deionised water (Millipore ELIX 10), pH was brought to 7.8+/- 0.2 via NaOH or H2SO4

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORAGNISMS
- Species: Daphnia magna STRAUS (HFA-strain C1)
- Age at study initiation: 1 - 24 h

Study design

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

24 h

Test conditions

Test temperature:

20 +/- 2 °C

pH:

7.8 +/- 0.2

Dissolved oxygen:

-

Salinity:

-

Conductivity:

-

Nominal and measured concentrations:

see Table 1 in 'Any other information on materials and methods incl. tables'

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Key result

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

>= 93 - <= 116 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mobility

Any other information on results incl. tables

Table 2: Test evaluation Daphina toxicity

	EC50, mL/L	EC50-range, mg/L
		< 1	1 - 10	10 – 100	> 100
Pyridobase	~0.09 (0.08 – 0.1)				X

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The EC50 value of pyridobase to Daphnia magna was found to be 93 - 116 mg/L (24 h).

Executive summary:

The 24h acute toxicity of pyridobase to Daphnia magna was studied under static conditions according to ISO 6341. Daphnids were exposed to the test chemical at nominal concentrations of 0, 0.1, 1, 10, 20, 40, 50, 60, 80, 100, 1000 mg/L for 24 hr. Mortality/immobilisation and sub-lethal effects were observed at the end of the study period. The 24 -hour EC50 was 93 to 116 mg/L.