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EC number: 258-203-7 | CAS number: 52821-24-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- N-ISOPROPYL-N’-PHENYL-P-PHENYLENEDIAMINE; CAS N°:101-72-4
- Author:
- OECD SIDS
- Year:
- 2 000
- Bibliographic source:
- OECD SIDS- SIDS Initial Assessment Report for SIAM 10 Tokyo, 15-17 March 2000
- Reference Type:
- secondary source
- Title:
- eye irritation for CAS 101-72-4 (1,4-benzenediamine, N-(1-methylethyl)-N'-phenyl)
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 017
- Bibliographic source:
- High Production Volume (HPV) Challenge Program; 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Eye irritation study of 1,4-benzenediamine, N-(1-methylethyl)-N'-phenyl (CAS no: 101-72-4) was conducted on six New Zealand White rabbits in order to determine the irritancy potential caused by the chemical.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,4-benzenediamine, N-(1-methylethyl)-N'-phenyl
- Cas Number:
- 101-72-4
- Molecular formula:
- C15H18N2
- IUPAC Name:
- 1,4-benzenediamine, N-(1-methylethyl)-N'-phenyl
- Test material form:
- solid
- Details on test material:
- - Name of test material: N-isopropyl-N'-phenyl-p-phenylenediamine
- Molecular formula: C15H18N2
- Molecular weight: 226.321 g/mol
- Smiles notation: c1(Nc2ccccc2)ccc(NC(C)C)cc1
- InChl: 1S/C15H18N2/c1-12(2)16-14-8-10-15(11-9-14)17-13-6-4-3-5-7-13/h3-12,16-17H,1-2H3
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: N-isopropyl-N'-phenyl-p-phenylenediamine
- Molecular formula: C15H18N2
- Molecular weight: 226.321 g/mol
- Smiles notation: c1(Nc2ccccc2)ccc(NC(C)C)cc1
- InChl: 1S/C15H18N2/c1-12(2)16-14-8-10-15(11-9-14)17-13-6-4-3-5-7-13/h3-12,16-17H,1-2H3
- Substance type: Organic
- Physical state: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- Amount :100%
concentration applied: 100mg - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- Immediate after treatment, and then at intervals of 10 minutes, 1 hour, and at 24, 48, 72 and 168 hours.
- Number of animals or in vitro replicates:
- 6 (male/female)
- Details on study design:
- TEST SITE
- Area of exposure: one eye of six albino rabbits
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24hour
SCORING SYSTEM: Draize, J.H., Woodard, G., and Calvery, H.O., 1944
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: Immediate findings
- Reversibility:
- not specified
- Remarks on result:
- other: slight discomfort.
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: At 10 minutes and 1 hour
- Reversibility:
- not specified
- Remarks on result:
- other: Slight erythema and discharge
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- other: slight erythema and discharge
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 and 72 hours
- Score:
- 0
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: The average Draize score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 110
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The conjunctival erythema observed at 24 hours in all the animals. There was no evidence of eye irritation at 48 hours in any of the animals.
Any other information on results incl. tables
Immediate findings: slight discomfort.
At 10 minutes: Slight erythema and discharge
At 1 hour: slight erythema and discharge
At 24 hours: slight erythema and discharge
At 48 hours: all animals scored "0"
At 72 hours: all animals scored "0"
The average Draize score for 24, 48 and 72 hours was 1.3.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material 1,4-benzenediamine, N-(1-methylethyl)-N'-phenyl (CAS no: 101-72-4) was considered to be not irritating to the eye of New Zealand White rabbits.
- Executive summary:
An eye irritation study of 1,4-benzenediamine, N-(1-methylethyl)-N'-phenyl (CAS no: 101-72-4) was conducted on six New Zealand White rabbits in order to determine the irritancy potential caused by the chemical.
Duringthetest100.0 mg of the undiluted test substance as a finely ground powder was applied to one eye of six albino rabbits. The other eye was not treated and served as a control. The cornea, iris and conjuntivae were examined immediately after treatment, and then at intervals of 10 minutes, 1 hour, and at 24, 48, 72 and 168 hours. The Draize Method was used for scoring eye irritation.
The average Draize score for 24, 48 and 72 hours was calculated for each animal and then averaged over the six animals. The average Draize score was 1.3 on scale from 0-110.
Since there was no evidence of eye irritation at 48 hours in any of the animals, the chemical 1,4-benzenediamine, N-(1-methylethyl)-N'-phenyl (CAS no: 101-72-4)was considered to benot irritatingto the eye ofNew Zealand Whiterabbits.
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