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EC number: 635-476-4 | CAS number: 88349-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Only very slight and transient skin irritation was seen in a rabbit skin irritation study performed with cloquintocet acid: classification for skin irritation is not required. Very slight and transient eye irritation was seen in a rabbit eye irritation study performed with cloquintocet acid: classification for eye irritation is not required.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
An acute dermal irritation study (Verma, 2013a) was conducted according to OECD guideline 404 in three adult male New Zealand White rabbits to assess the potential of the test substance to cause irritation or corrosion to intact skin following a 4 -hour exposure period. The test substance (500 mg) was moistened with 50 mL of distilled water and applied to the treatment skin sites, with a surface of approximately 6 cm². Initially one rabbit was tested. Based on the observations at 24 hour post-patch removal, two additional rabbits were tested simultaneously to confirm the irritation response. The test substance caused a mild and transient local reaction to the treated skin. The mean dermal irritation scores at 24, 48 and 72 hours post-patch removal for individual animals were 0.00, 0.33, 0.33 for erythema and 0.00, 0.00, 0.00 for oedema.
Eye Irritation:
An acute eye irritation study (Verma, 2013b) was conducted according to OECD guideline 405 in three adult female New Zealand White rabbits to assess the potential of the test substance (0.1 mL) to cause irritation or corrosion to the eye. Initially one rabbit was tested. Based on the results obtained at 24 hours post-application, the irritation response was confirmed by testing two additional rabbits simultaneously. The test substance caused a mild eye irritation which resolved by 72 hours post test item application. The individual animal mean eye irritation scores at the 24, 48 and 72 h observation were 0.00, 0.00, 0.00 for corneal opacity, 0.00, 0.00, 0.00 for iris effects, 1.00, 1.00, 1.00 for conjunctival redness and 0.67, 0.00, 0.67 for conjunctival chemosis for rabbit N° 1, 2 and 3, respectively.
In vitro studies are not required due to the availability of in vivo data.
Justification for classification or non-classification
Skin irritation/corrosion:
Cloquintocet acid only caused slight irritation in a skin irritation/corrosion study. Therefore, cloquintocet acid does not therefore require classification as a skin irritant according to the CLP Regulation 1272/2008.
Eye irritation/corrosion:
Cloquintocet acid only caused slight irritation in an eye irritation/corrosion study. Therefore, cloquintocet acid does not therefore require classification as an eye irritant according to the CLP Regulation 1272/2008.
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