Registration Dossier
Registration Dossier
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EC number: 813-266-5 | CAS number: 45101-66-4
Carcinogenicity
Administrative data
Description of key information
Low concern for cancer in humans for 6-chlorohexyl methacrylate (6-CHMA) should be assumed based on data for similar substances belong to the category "short chain alkyl methacrylates".
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Low concernfor cancer in humansof 6-chlorohexyl methacrylate (6-CHMA) should be assumed based on its similarity with short chain alkyl methacrylates.
No classification for carcinogenicity of 6-chlorohexyl methacrylate (6-CHMA)is proposed according to the CLP Regulation (EC n.1272/2008).
Additional information
No carcinogenicity studies have been conducted on 6-chlorohexyl methacrylate (6-CHMA) and on the similar substances belong to the category "short chain alkyl methacrylates" (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier).
In SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) this general consideration is reported: "None of the esters are genotoxic in in-vitroor in-vivo assays. No epidemiological (cancer mortality) studies have been reported in the literature on any members of the category. Several cancer mortality studies have been reported on the reference chemical, methyl methacrylates (MMA, CAS 80-62-6), and these, together with the negative genotoxicity and cancer bioassays in rodents, indicate a low concern for cancer in humans".
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