Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
Cadmium Metal and Cadmium Oxide - Summary Risk Assessment Report
Author:
European Chemicals Bureau
Year:
2008
Bibliographic source:
European Chemicals Bureau

Materials and methods

Principles of method if other than guideline:
Methodology not outlined in reference report
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent

Test animals

Species:
other: studies on rats and mice

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 72 - < 300 mg/kg bw
Remarks on result:
other: these are values for CdO

Any other information on results incl. tables

Studies on CdO and Cd metal show that LD50 oral values (rat and mouse) range from 72 to 300 mg CdO/kg (63-259 mg Cd/kg) and from 50 to 400 mg Cd/kg for water-soluble compounds. Experiments using cadmium compounds provide additional information about the target organs of ingested cadmium at acute toxicity doses: targets were the proximal parts of the intestinal tract. The emetic threshold dose for cadmium (element) in drinking water has been estimated to be in the order of 15 mg/l. The no-effect level of a single oral dose for humans is estimated at 3 mg elemental Cd and the lethal doses range from 350 to 8,900 mg.

Applicant's summary and conclusion

Conclusions:
Because of the chemical similarity of the candidate substance and cadmium oxide, the oral LD50 values reported for cadmium oxide are also applicable to the candidate substance.